Intralesional Vitamin D3 Versus Intralesional Triamcinolone Acetonide in Patchy Alopecia Areata: A Comparative Clinical and Dermoscopic Study

August 2024 in “ Journal of Cosmetic and Laser Therapy ”

Maha H. Ragaie, Shimaa E. Mohammed, Shimaa S. Shehata

intralesional vitamin D3 intralesional triamcinolone acetonide patchy alopecia areata trichoscopic signs vitamin D3 injections triamcinolone injections

Studysummary This study found that intralesional vitamin D3 achieved similar effectiveness to triamcinolone acetonide for treating patchy alopecia areata but was associated with fewer adverse effects and higher patient satisfaction. Our plain-language summary of this paper — not a Tressless recommendation.

The study compares the efficacy of intralesional vitamin D3 versus intralesional triamcinolone acetonide in treating patchy alopecia areata. It involved a clinical and dermoscopic evaluation to determine which treatment is more effective. The results indicated that both treatments were effective, but the study provides insights into their comparative benefits and potential side effects. The findings suggest that intralesional vitamin D3 could be a viable alternative to triamcinolone acetonide, offering a different mechanism of action for managing alopecia areata.

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research Intralesional Vitamin D3 in Treatment of Alopecia Areata: A Randomized Controlled Clinical Trial

7 citations , February 2022 in “Journal of Cosmetic Dermatology”

In this randomized controlled trial, intralesional vitamin D3 injections significantly improved localized alopecia areata symptoms compared to a saline placebo, with minimal and transient side effects, suggesting vitamin D3 as an effective treatment option without needing prior serum vitamin D level measurement.

research Role of Vitamin D in Hair Loss: A Short Review

14 citations , September 2021 in “Journal of Cosmetic Dermatology”

This review discusses vitamin D's role in hair follicle biology and its association with hair loss but reports no conclusive evidence for its effectiveness as a treatment, indicating the need for further studies.

research Alopecia Areata: Overview and Insights from January 2018

290 citations , December 2017 in “Journal of The American Academy of Dermatology”

This article reviews the epidemiology, clinical evaluation, and pathogenesis of alopecia areata and highlights recent advancements, but it does not report new clinical findings.

research The Role of Vitamin D in Non-Scarring Alopecia

32 citations , December 2017 in “International Journal of Molecular Sciences”

This review suggests that decreased serum 25-hydroxyvitamin D levels may play a role in different types of non-scarring alopecia, but further studies are needed to explore vitamin D supplementation as a therapeutic option.

research Dermoscopic Evaluation of Therapeutic Response to Intralesional Triamcinolone Acetonide in the Treatment of Alopecia Areata

3 citations , July 2017 in “International journal of medicine”

In this study, 70 patients with alopecia areata who received intralesional triamcinolone showed a significant reduction in black dots, yellow dots, broken hair, and tapering hair, while achieving a 60% success rate in hair regrowth.

research Efficacy and Safety of Topical Calcipotriol in Management of Alopecia Areata: A Pilot Study

39 citations , January 2017 in “Dermatologic Therapy”

This study found that topical calcipotriol lotion resulted in hair regrowth in 59.1% of alopecia areata patients, with better response observed in those with lower serum vitamin D levels.

research Dermoscopic Evaluation of Therapeutic Response to an Intralesional Corticosteroid in the Treatment of Alopecia Areata

35 citations , January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

This study found that intralesional triamcinolone acetonide is effective for treating localized patchy alopecia areata, with dermoscopy aiding in early detection of clinical response and adverse effects.

Randomized Comparison of Topical Betamethasone Valerate Foam, Intralesional Triamcinolone Acetonide, and Tacrolimus Ointment in Management of Localized Alopecia Areata

research Randomized Comparison of Topical Betamethasone Valerate Foam, Intralesional Triamcinolone Acetonide, and Tacrolimus Ointment in Management of Localized Alopecia Areata

48 citations , January 2011 in “International journal of trichology”

This study found that intralesional triamcinolone acetonide was most effective for hair regrowth in localized alopecia areata, with betamethasone valerate foam also being beneficial, while tacrolimus ointment showed no significant effect.

research The Pattern and Profile of Alopecia Areata in Singapore: A Study of 219 Asians

275 citations , November 2002 in “International Journal of Dermatology”

This study found that among an Asian population with alopecia areata, commonly first episodes occurred before age 40, with severe cases linked to psychological effects and treatments showing significant regrowth.