TLDR The new cryo-MAP technique enables rapid and successful hair growth by transplanting hair follicle organoids.
This study introduces a cryo-microneedles array patch (cryo-MAP) technique for transplanting 3D hair follicle organoids, which are cultured without a matrix or serum and preserved with low-DMSO cryopreservation. The method avoids growth suppression from hydrogels, allowing hair follicles to germinate within 3 days. Proteomics analysis showed that cryopreservation maintained high cell viability and enhanced the organoids' differentiation capacity. The transplanted organoids successfully regenerated complex skin structures, achieving hair growth through the skin in about 15 days with a success rate of over 86%. This advancement presents new opportunities for organoid transplantation in tissue engineering and regenerative medicine.
February 2025 in “Stem Cell Research & Therapy” Hair follicle regeneration is advancing but still faces challenges in stability and clinical use.
30 citations
,
April 2020 in “Stem Cell Research & Therapy” PI3K/Akt pathway is crucial for hair growth and regeneration.
45 citations
,
November 2017 in “Biomaterials” Researchers found a new way to create hair-growing structures in the lab that can grow hair when put into mice.
92 citations
,
August 2017 in “Proceedings of the National Academy of Sciences of the United States of America” Newborn mouse skin cells can grow hair and this process can be recreated in adult cells to potentially help with hair loss.
179 citations
,
April 2012 in “Nature Communications” Regenerated fully functional hair follicles using stem cells, with potential for hair regrowth therapy.
561 citations
,
April 2003 in “Journal of Investigative Dermatology” CD34 is a marker for isolating stem-like cells in mouse hair follicles.
July 2024 in “Journal of Nanobiotechnology” Mouse cell exosomes help hair regrowth and wound healing by activating a specific signaling pathway.
August 2025 in “Plastic and Aesthetic Research” Microneedling can effectively treat hair loss and works well with other treatments, but more research is needed.
July 2025 in “Bioactive Materials” New engineering methods show promise for regenerating hair follicles using stem cells and advanced technologies.
January 2025 in “SSRN Electronic Journal” 
Proretinal nanoparticles are a safe and effective way to deliver retinal to the skin.
