Matrix-Free Cryo-Microneedles Array Patch for 3D Hair Follicle Organoids Delivery and Rapid Hair Regeneration

    March 2026 in “ Materials Today Bio ”
    Shu Wang, Jie Sun, Yu Li … Zhuoying Xie
    Studysummary This study developed a minimally invasive cryo-microneedles array patch (cryo-MAP) technique for transplanting hair follicle organoids, showing successful hair growth and complex skin structure regeneration with over 86% success in 15 days, opening new possibilities in tissue engineering.
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    Research cited in this study 6

    1. Functional Regeneration Strategies of Hair Follicles: Advances and Challenges Stem Cell Research & Therapy · 2025
    2. PI3K/Akt Signaling Pathway Is Essential for De Novo Hair Follicle Regeneration Stem Cell Research & Therapy · 2020
    3. Spontaneous Hair Follicle Germ Formation In Vitro, Enabling The Large-Scale Production Of HFGs For Regenerative Medicine Biomaterials · 2017
    4. Self-Organization Process in Newborn Skin Organoid Formation Inspires Strategy to Restore Hair Regeneration of Adult Cells Proceedings of the National Academy of Sciences of the United States of America · 2017
    5. Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches Nature Communications · 2012
    6. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003