No Prevention of Radiotherapy-Induced Alopecia by Scalp Cooling

The document discusses the distressing side effect of baldness in patients undergoing whole brain radiotherapy (WBRT) and explores the potential of scalp cooling, a method shown to prevent chemotherapy-induced alopecia, as a means to reduce radiotherapy-induced hair loss. The hypothesis is based on the idea that scalp cooling could lead to reduced tissue oxygenation and hair follicle cell hypoxia, making the cells more resistant to radiation damage due to the decreased formation of oxygen radicals, which in turn could prevent DNA breaks and cell death. However, the title of the document suggests that this method was not successful in preventing hair loss due to radiotherapy.