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This narrative review evaluates evidence that regional hypothermia can reduce oral, hair, eye, and nail complications from chemotherapy, but highlights the need for more research to address study limitations.

This narrative review found that cryotherapy resulted in approximately 60% hair regrowth response in alopecia areata patients, with some evidence suggesting lower relapse rates compared to intralesional steroid injection, although no statistically significant difference in efficacy was identified.

This study found that ablative fractional carbon dioxide laser treatment improved skin fibrosis, reduced skin hardening, and enhanced hair follicle growth in localized scleroderma patients, with significant improvements across several clinical measures and no severe adverse effects observed.

In this case report, researchers observed that scalp cooling during chemotherapy with doxorubicin and cyclophosphamide allowed a pregnant breast cancer patient to preserve nearly all her hair, suggesting such treatment may be a safe and effective option for managing chemotherapy-related hair loss during pregnancy.

This case series found that combining ablative fractional resurfacing and acoustic pressure ultrasound with triamcinolone treatment led to complete recovery in patients with areata alopecia.

In this study on patchy alopecia areata treatment involving 20 patients, TCA (triamcinolone acetonide) injections showed a significantly better response and minimal side effects compared to superficial cryotherapy.

This study found that over 80% of women treated with paclitaxel who used a hypothermic glycerin-based hydrogel cap preserved at least 50% of their initial hair volume, suggesting scalp cooling may effectively prevent chemotherapy-induced alopecia.

This article reviews historical approaches to electrolysis for permanent hair removal and suggests improvements in equipment, but reports no new clinical results.

In this chapter, the authors provide a detailed overview of the fundamental science and operational principles of radiofrequency technologies, particularly in enhancing liposuction procedures through minimally-invasive techniques like RF-assisted lipolysis and fractional RF subdermal treatment.

In this randomized controlled trial at Bolan Medical Complex Hospital, researchers observed that liquid nitrogen cryotherapy increased hair regrowth by 60% in alopecia areata patients, significantly outperforming alternative treatments, which achieved 40% regrowth.

Intralesional corticosteroids may be more effective than cryotherapy for hair regrowth in alopecia areata.

This review discusses the use of ablative and nonablative fractional resurfacing for enhanced topical drug delivery in dermatology and reports no new clinical results; further studies are needed to explore these methods.

This article reviews the pathophysiology of chemotherapy-induced alopecia and reports that scalp cooling can reduce hair loss by 50% in patients with early breast cancer receiving chemotherapy, without compromising survival or increasing scalp metastasis risk.

This review discusses the historical, legal, and clinical aspects of electrolysis and thermolysis, highlighting potential risks due to the lack of standardized training for electrologists in the United States, but reports no new clinical results.

This review discusses the potential of cold atmospheric plasma as a selective antitumor therapy for breast cancer but reports no clinical results, emphasizing its promise and the challenges to its use in precision oncology.

This study reported cold thermal injuries on the scalp in four patients using cold caps to prevent chemotherapy-induced alopecia, suggesting improper application can lead to adverse events.

This article reviews the potential and limitations of cryotherapy for alopecia areata in middle-aged patients and highlights the need for further research, without reporting new clinical findings.

Scalp cooling reduces chemotherapy-induced hair loss without increasing risk of skin metastases.

This study compared the microscopic treatment zones created by different fractional lasers and radiofrequency in swine skin, finding distinct patterns and damage levels for each technology.

In a systematic review and meta-analysis, the researchers found that intralesional triamcinolone acetonide was more effective than cryotherapy for achieving significant hair regrowth in patients with patchy alopecia areata, although both treatments had distinct safety profiles.

This study will evaluate the clinical efficacy, patient-reported outcomes, and economic impact of the PAXMAN® PSCS 2 automated scalp cooling system versus standard cold-cap therapy to prevent chemotherapy-induced hair loss in women with localized breast cancer during anthracycline and taxane treatment.

This study found that using low-power lasers on cryosurgery-induced wounds in rats can prevent hair follicle necrosis and increase hair follicle numbers, with the experimental group showing significantly more hair follicles than the control group across all time points studied.

This study found that using an argon gas-based system for intralesional cryotherapy significantly reduced keloid scar volume, improved scar quality, and resulted in low recurrence rates after 12 months.

This study observed that using ice pack compression or a vibration anesthesia device reduced pain during inactivated PRP scalp injections in patients with alopecia, suggesting both as inexpensive and accessible pain-relief options.

This study demonstrated that ablation of individual somatostatin-expressing interneurons increased activity in nearby neurons of the mouse motor cortex during motor learning.

This study found that cooling combined with antioxidants can improve scalp cooling effectiveness in preventing chemotherapy-induced alopecia by maintaining hair follicle viability and function.

This study found that combining high-density fat grafting with botulinum toxin A significantly improved symptoms of Raynaud’s phenomenon, including reducing pain and cold sensitivity, speeding up ulcer healing, and enhancing blood perfusion, compared to fat grafting alone.

This abstract describes the Dermatologic Surgery journal's extensive focus on skin surgery procedures, but it presents no new research findings.

This study used numerical models to explore the cooling power required by different scalp cooling devices to prevent chemotherapy-induced hair loss, finding that coolant temperature significantly influences scalp tissue temperatures.

This study found that the computer-controlled RV-01 scalp cooling device helped prevent significant hair loss in metastatic breast cancer patients treated with eribulin, with none of the 16 patients requiring a wig and experiencing minimal discomfort.