Abstract P1-12-19: Successful Hair Preservation Using Scalp Cooling with Doxorubicin and Cyclophosphamide During Pregnancy
June 2025
in “
Clinical Cancer Research
”
Studysummary In this case report, researchers observed that scalp cooling during chemotherapy with doxorubicin and cyclophosphamide allowed a pregnant breast cancer patient to preserve nearly all her hair, suggesting such treatment may be a safe and effective option for managing chemotherapy-related hair loss during pregnancy. Our plain-language summary of this paper — not a Tressless recommendation.
This case report details the successful use of scalp cooling to preserve hair in a 38-year-old pregnant woman undergoing chemotherapy with doxorubicin and cyclophosphamide (AC) for breast cancer. Despite the common occurrence of hair loss with AC, the patient retained nearly 100% of her hair after 4 cycles, and experienced minimal hair loss (<5%) during subsequent treatment with paclitaxel, trastuzumab, and pertuzumab postpartum. The report highlights the potential effectiveness and safety of scalp cooling during pregnancy, suggesting that pregnancy-related hair changes may contribute to hair preservation. This case underscores the importance of considering scalp cooling to alleviate the psychological distress of alopecia in pregnant patients undergoing chemotherapy.
