Abstract P1-12-19: Successful Hair Preservation Using Scalp Cooling with Doxorubicin and Cyclophosphamide During Pregnancy

June 2025 in “ Clinical Cancer Research ”

Kelsey Natsuhara, Annalisa Post, Michael Alvarado, Sally Fang-Tu, Gustavo O. Fulgêncio, A. Jo Chien

scalp cooling doxorubicin cyclophosphamide chemotherapy-induced alopecia hair follicle cycling AC chemotherapy

TLDR Scalp cooling can effectively prevent hair loss during chemotherapy in pregnancy.

This case report details the successful use of scalp cooling to preserve hair in a 38-year-old pregnant woman undergoing chemotherapy with doxorubicin and cyclophosphamide (AC) for breast cancer. Despite the common occurrence of hair loss with AC, the patient retained nearly 100% of her hair after 4 cycles, and experienced minimal hair loss (<5%) during subsequent treatment with paclitaxel, trastuzumab, and pertuzumab postpartum. The report highlights the potential effectiveness and safety of scalp cooling during pregnancy, suggesting that pregnancy-related hair changes may contribute to hair preservation. This case underscores the importance of considering scalp cooling to alleviate the psychological distress of alopecia in pregnant patients undergoing chemotherapy.

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