Experience of a Private Hospital in the Federal District in Cryotherapy with a Hypothermal Cap for Patients Using Paclitaxel 80 mg/m² Weekly for 12 Weeks

January 2021 in “ Mastology ”

Patrícia Werlang Schorn, Juçara Motta Serafim Eliam, André Moreira Lemes, Caroli ne Alves de Souza Ramos, Juliana Sinezio Santos, Lenisa Cezar Vilas Boas, Elyse Carvalho Borges dos Santos de Figuerêdo

cryotherapy hypothermal cap paclitaxel chemotherapy-induced alopecia scalp cooling glycerin-based hydrogel cap alopecia Common Terminology Criteria for Adverse Events CTCAEv4 Dean scale scalp cooling therapy chemotherapy-induced hair loss

TLDR Scalp cooling therapy helped over 80% of women keep at least half their hair during chemotherapy.

In a retrospective study conducted from 2014 to 2018 at a private hospital in the Federal District, 92 women undergoing weekly chemotherapy with paclitaxel 80 mg/m² for 12 weeks used a hypothermic glycerin-based hydrogel cap to prevent chemotherapy-induced alopecia (CIA). The study aimed to evaluate the effectiveness of this scalp cooling method in preserving hair volume. At the end of the treatment, 83% of patients experienced only grade 1 alopecia according to the Common Terminology Criteria for Adverse Events version 4 (CTCAEv4), and based on the modified Dean scale, 71% had grade 1 alopecia, 12% grade 2, 7.5% grade 3, and 9.5% grade 4. The results indicated that over 80% of the women retained at least 50% of their initial hair volume, demonstrating that scalp cooling therapy can be an effective measure to reduce the emotional and aesthetic impact of hair loss in patients treated with paclitaxel.

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