Scalp Cooling Versus Standard Cold-Cap in Preventing Chemotherapy-Induced Alopecia in Patients With Localized Breast Cancer: ICELAND Protocol, a Randomized Controlled Trial and Economic Evaluation

    August 2026 in “ PLoS ONE ”
    François Gernier, Justine Lequesne, Jean‐Michel Grellard … Bénédicte Clarisse
    Studysummary This study will evaluate the clinical efficacy, patient-reported outcomes, and economic impact of the PAXMAN® PSCS 2 automated scalp cooling system versus standard cold-cap therapy to prevent chemotherapy-induced hair loss in women with localized breast cancer during anthracycline and taxane treatment.
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    Research cited in this study 2

    1. Permanent Chemotherapy-Induced Alopecia in Patients with Breast Cancer: A 3-Year Prospective Cohort Study ˜The œoncologist · 2018
    2. Persistent Major Alopecia Following Adjuvant Docetaxel for Breast Cancer: Incidence, Characteristics, and Prevention with Scalp Cooling Breast Cancer Research and Treatment · 2018