The Effect of Local Skin Precooling on Alleviating Injection Site Pain in Patients With Androgenetic Alopecia Receiving a Scalp Nerve Block

March 2025 in “ Pain Physician ”

Rashid M. Rashid, Kenneth D. Candido, Shariq Ibrahim, Bangda Chai, Ling Gao, Song Yan-ling, Yue Wang, Xiao-wen Pan, Wenjun Le, Wei-Ting Liu, Zhongmin Liu

androgenetic alopecia local skin precooling scalp nerve block platelet-rich plasma mesotherapy LSPC SNB PRP

TLDR Cooling the skin before injections reduces pain for patients with hair loss.

The study conducted at Shanghai East Hospital examined the impact of local skin precooling (LSPC) on reducing pain during scalp nerve block (SNB) in 100 patients with androgenetic alopecia undergoing platelet-rich plasma (PRP) mesotherapy. Participants were divided into two groups, with one group receiving LSPC before SNB. Results indicated that the precooling group experienced significantly lower pain levels, with a 34.08% reduction at certain nerve points. The study concluded that LSPC is a simple and effective method to enhance patient comfort and compliance during PRP mesotherapy, despite limitations such as its retrospective nature and small sample size.

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