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    Glossary Corticotropin-Releasing Hormone

    peptide hormone that triggers stress response via ACTH release

    Corticotropin-Releasing Hormone (CRH) is a peptide hormone involved in the stress response. It is produced by the hypothalamus and stimulates the pituitary gland to release adrenocorticotropic hormone (ACTH), which in turn prompts the adrenal glands to produce cortisol, a key stress hormone. CRH also plays a role in various bodily functions, including immune response and skin health, and has been linked to conditions like alopecia, where stress can exacerbate hair loss.

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    Research 30 of 568

    1. Increased CRHR1 expression on monocytes from patients with AA enables a pro‐inflammatory response to corticotrophin‐releasing hormone Experimental Dermatology · 2024 · 3 citations
    2. Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus? Postepy Dermatologii I Alergologii · 2017
    3. Corticotropin releasing hormone and the skin Frontiers in bioscience · 2006 · 137 citations
    4. Corticotropin releasing factor-1 receptor antagonism associated with favorable outcomes of male reproductive health biochemical parameters Frontiers in Endocrinology · 2023
    5. Corticotropin-Releasing Factor Down-Regulates Hair Growth-Related Cytokines in Cultured Human Dermal Papilla Cells Journal of the Society of Cosmetic Scientists of Korea · 2014 · 1 citations
    6. Hormonal regulation in male androgenetic alopecia—Sex hormones and beyond: Evidence from recent genetic studies Experimental Dermatology · 2020 · 15 citations
    7. An implication for post-transcriptional control: Reciprocal changes of melanocortin receptor type 2 mRNA and protein expression in alopecia areata Medical Hypotheses · 2010 · 7 citations
    8. Corticotropin-releasing hormone: An autocrine hormone that promotes lipogenesis in human sebocytes Proceedings of the National Academy of Sciences · 2002 · 284 citations
    9. New effects of caffeine on corticotropin‐releasing hormone (CRH)‐induced stress along the intrafollicular classical hypothalamic–pituitary–adrenal (HPA) axis (CRH‐R1/2, IP<sub>3</sub>‐R, ACTH, MC‐R2) and the neurogenic non‐HPA axis (substance P, p75<sup>NTR</sup>and TrkA) in<i>ex vivo</i>human male androgenetic scalp hair follicles British Journal of Dermatology · 2020 · 12 citations
    10. The Skin POMC System (SPS): Leads and Lessons from the Hair Follicle Annals of the New York Academy of Sciences · 1999 · 66 citations
    11. Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA<sub>A</sub>Receptors Journal of Neuroscience · 2011 · 248 citations
    12. Psychophysiological Mechanisms of Stress Impact on Hair Loss Processes International Journal of Science and Research (IJSR) · 2025
    13. Diffuser Haarausfall und klinische Endokrinologie: Neue Erkenntnisse Journal für Kardiologie (Krause & Pachernegg GmbH) · 2013
    14. “Sebocytes’ makeup” - Novel mechanisms and concepts in the physiology of the human sebaceous glands 2011 · 58 citations
    15. The local hypothalamic–pituitary–adrenal axis in cultured human dermal papilla cells BMC Molecular and Cell Biology · 2020 · 9 citations
    16. Hormonal acne: leading to a paradigm shift in the management of acne Expert Review of Dermatology · 2013
    17. Human hair follicles display a functional equivalent of the hypothalamic‐pituitary‐adrenal (HPA) axis and synthesize cortisol The FASEB Journal · 2005 · 489 citations
    18. Cutaneous neuroimmunology – lessons from the hair follicle Experimental Dermatology · 2004
    19. New frontiers in human hair follicle (neuro‐)endocrinology Experimental dermatology · 2006
    20. The human skin as a hormone target and an endocrine gland Hormones · 2004 · 146 citations
    21. Stress Hormone and Skin Disease InTech eBooks · 2011 · 2 citations
    22. Stress-related skin disorders Reviews in Endocrine and Metabolic Disorders · 2016 · 67 citations
    23. Neuroendocrinology of the hair follicle: principles and clinical perspectives Trends in Molecular Medicine · 2014 · 98 citations
    24. Thyrotropin-releasing hormone and oestrogen differentially regulate prolactin and prolactin receptor expression in female human skin and hair follicles <i>in vitro</i> British Journal of Dermatology · 2010 · 37 citations
    25. Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells Annals of Medicine · 2025
    26. Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells 2025
    27. Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells 2025
    28. An N-Ethyl-N-Nitrosourea Induced Corticotropin-Releasing Hormone Promoter Mutation Provides a Mouse Model for Endogenous Glucocorticoid Excess Endocrinology · 2013 · 27 citations
    29. Ganoderma lucidum extract attenuates corticotropin-releasing hormone induced cellular senescence in human hair follicle cells iScience · 2024
    30. Hormone therapy in acne Indian Journal of Dermatology, Venereology and Leprology · 2013 · 24 citations