1 citations
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August 2021 in “International Journal of General Medicine” This study found that androgenic alopecia is independently associated with increased coronary artery disease risk and severity of coronary atherosclerosis among Han Chinese men.
January 1986 in “Journal of Steroid Biochemistry” Lower testosterone levels in men may be linked to a higher risk of severe coronary artery disease.
1 citations
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November 2001 in “Acc Current Journal Review” This review found that 5α‐reductase inhibitors were associated with slightly increased rates of decreased libido, erectile and ejaculatory dysfunction, gynecomastia, and mood disorders compared to placebo, though their long-term effects remain unclear.
15 citations
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January 2000 in “Japanese Heart Journal” This case report discusses a 45-year-old Japanese man who developed myocardial infarction while using 1% topical minoxidil for baldness, highlighting the need for caution in patients with cardiovascular disorders.
17 citations
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June 2012 in “The Anatolian journal of cardiology” This study found that increased hair graying was associated with a greater coronary atherosclerotic burden, suggesting it could serve as a risk marker for coronary artery disease independent of age.
2 citations
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November 2017 in “Cardiovascular endocrinology” This study found that androgenic alopecia is the strongest predictor of coronary artery disease in young men from Western India, followed by premature graying and obesity.
In this observational study, men with early onset androgenic alopecia exhibited a statistically significant correlation with more severe forms of coronary artery disease compared to those without the condition.
January 2026 in “American Journal of Translational Research” In this study, the combination of metoprolol and spironolactone in patients with coronary heart disease and heart failure significantly improved cardiac function and reduced inflammation and oxidative stress markers compared to spironolactone alone, with better clinical efficacy and fewer adverse effects.
January 2021 in “ABC Heart Failure & Cardiomyopathy” This article discusses the coexistence of amyloidosis and aortic stenosis in elderly patients and explores potential therapeutic strategies, without reporting new clinical results.
1 citations
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January 2006 This study found a positive association between bilateral diagonal earlobe crease and bilateral preauricular crease with coronary artery disease, with both creases together predicting the disease with 90% accuracy.
10 citations
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April 2015 in “Netherlands Heart Journal” This study concluded that there is no association between male pattern baldness and the severity or presence of coronary artery disease as measured by Gensini and Rentrop scores.
1 citations
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July 2025 in “Scientific Reports” This study found that combining diagonal earlobe crease with lipoprotein(a) provides strong diagnostic value for coronary heart disease.
3 citations
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March 2012 in “Hair transplant forum international” This article reviews the importance of managing perioperative antithrombotic therapy to prevent cardiovascular events in patients with coronary heart disease or atrial fibrillation during surgery and reports no new findings.
18 citations
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June 1998 in “Circulation” This letter discusses how outdated measurement technology may obscure evidence of essential fatty acid deficiency in low-fat diet patients, potentially leading to undiagnosed EFA insufficiencies related to heart disease.
38 citations
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February 2009 in “Journal of The European Academy of Dermatology and Venereology” This study found that patients with severe vertex pattern androgenetic alopecia had significantly higher carotid intima-media thickness, suggesting an increased risk of subclinical atherosclerosis compared to other alopecia patterns and healthy controls.
3 citations
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January 2019 in “International Journal of Trichology” This study suggests that female pattern baldness may be a marker for increased risk of coronary artery disease events among women.
January 2015 in “Indian Journal of Medical Biochemistry” Men with early balding should be checked for metabolic syndrome, as there's a link between the two.
4 citations
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October 2022 in “American journal of physiology. Heart and circulatory physiology” This study found that in patients with severe aortic valve stenosis, higher serum dihydrotestosterone levels were associated with increased myocardial hypertrophy, fibrosis, and reduced left ventricular function.
January 2020 in “Turk Dermatoloji Dergisi” In this study, androgenetic alopecia, diagonal earlobe crease, and hairy ear were more frequently observed in men with coronary artery disease compared to controls.
March 2026 in “Nutrients” This study found that hair manganese levels did not vary by acute coronary syndrome or stable coronary artery disease severity, but a modest, non-significant correlation with body mass index suggests a potential link between manganese homeostasis and cardiometabolic status that warrants further investigation.
June 2023 in “Frontiers in Cardiovascular Medicine” This review identified two promising therapeutic targets for drug repurposing to treat refractory angina in patients with angina pectoris without obstructive coronary artery disease: endothelin-1 receptor blockers and soluble guanylate cyclase stimulators.
November 2023 in “Biology” This study investigated 130 patients and found a significant inverse correlation between copper content and the copper/zinc ratio in hair samples and the extent of coronary artery disease, while zinc content alone showed no significant relationship with disease extent.
1 citations
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October 2025 in “Frontiers in Cardiovascular Medicine” This review examines AAS-related deaths and finds that anabolic-androgenic steroid abuse may lead to severe cardiac abnormalities, contributing to fatal arrhythmias and sudden cardiac death in young athletes and bodybuilders.
29 citations
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October 2020 in “eLife” This study using Mendelian randomization in UK Biobank data suggests that lifelong increased free testosterone may have mixed effects, including increased bone density and prostate cancer risk, warranting well-powered trials to address uncertainties.
2 citations
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September 2020 This Mendelian randomization study reports that lifelong increased free testosterone in males was associated with improved bone mineral density and body composition but increased risks of prostate cancer, hypertension, and several other conditions.
This study using Mendelian randomization suggests lifelong increased free testosterone in males may have beneficial effects such as increased bone mineral density and decreased body fat, but also increased risks of prostate cancer and hypertension.
This study observed significant differences in trace element hair-scalp concentrations associated with atherosclerosis in coronary and carotid disease patients, suggesting that zinc levels and lymphocyte count interactions may significantly influence cardiovascular disease development.
336 citations
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August 2015 in “European Journal of Epidemiology” This article reviews the design and objectives of the Rotterdam Study, as well as summarizes major findings, without reporting new results.
266 citations
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November 2013 in “European Journal of Epidemiology” This article outlines the rationale and design of the Rotterdam Study, summarizes its major findings, and updates its objectives and methods; it reports no new research results.
January 2016 in “Ankara Üniversitesi Tıp Fakültesi mecmuası” Severe hair loss (androgenetic alopecia) is linked to higher risk of heart disease (cardiovascular atherosclerosis).