Diagnostic Value of the Diagonal Earlobe Crease in Combination with Lipoprotein(a) in Coronary Heart Disease

    July 2025 in “ Scientific Reports
    Ruoling Guo, Huihui Yang, Jie Dou, Jie Gao, Yuhua Yin, Yu Gu, Lina Liu, Yanchun Yang, Jingtao Guo, Dapeng Zhou, Dong-Lei Luo
    TLDR Diagonal earlobe crease and lipoprotein(a) together help diagnose coronary heart disease.
    The study investigated the diagnostic value of diagonal earlobe crease (DELC) combined with lipoprotein(a) [Lp(a)] for coronary heart disease (CHD) in 862 patients with chest pain. Results indicated that both DELC and Lp(a) are positively correlated with CHD and serve as independent risk factors. The diagnostic model, which included age, sex, hypertension, diabetes mellitus, alopecia, DELC, triglycerides (TG), and Lp(a), showed a good fit with a Hosmer-Lemeshow test P-value of 0.683. The area under the curve (AUC) for DELC and Lp(a) was 0.729, demonstrating strong diagnostic value for CHD. The combination of DELC and Lp(a) is valuable for diagnosing CHD.
    Discuss this study in the Community →