May 2026 in “International Journal of Drug Delivery Technology” This source describes how androgenic alopecia, or pattern hair loss, affects about 70% of men and is linked to factors like stress, hormonal imbalances, and lifestyle issues, which can also impact psychological well-being and potentially contribute to severe health conditions such as heart disease.
This study suggests that 9-Octadecenoic acid (Z)-, 2,3-dihydroxypropyl ester from African Yam bean seeds may inhibit the human 5α-reductase II enzyme, potentially helping manage BPH, although further studies are needed.
January 2025 in “Journal of Medical Biochemistry” This review explores the roles of superoxide dismutases in cellular processes and cancer, highlighting the potential of SOD mimetics in enhancing cancer treatment strategies, but it reports no new clinical findings.
March 2024 in “International Journal of Drug Delivery Technology” This study reviews the potential of electrospun nanofiber mats as innovative drug delivery systems for wound healing, emphasizing their ability to enhance drug release, improve cell adhesion, and promote tissue regeneration by incorporating antibiotics, growth hormones, or stem cells.
January 2024 in “International journal of pharmaceutical sciences review and research” This review paper critically evaluates the pharmacological and toxicological effects of Ziziphus mauritiana, a plant with traditional medicinal use, highlighting its anxiolytic, antioxidant, antimicrobial, anti-cancer, anti-diabetic, and anti-ulcer properties attributed to its rich phytochemical composition.
February 2023 in “Aesthetic Cosmetology and Medicine” This review examines the health-promoting effects of medicinal plants used in nutricosmetics, highlighting their beneficial impact on skin physiology, but offers no new clinical results.
January 2017 in “Clinical approaches and procedures in cosmetic dermatology” This study highlights the roles of dietary nutrients in maintaining skin health, noting that shortages can lead to hard-to-detect dysfunctions, and suggests that nutraceuticals may help address these nutritional gaps and improve skin-related issues linked to aging and dermatoses.
January 2014 in “Journal of Clinical and Investigative Dermatology” This study observed that young rat models, with naturally synchronized hair growth phases, developed total alopecia after chemotherapy and may serve as a better model for testing CIA protective treatments compared to adult rats.
59 citations
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June 2008 in “Journal of The American Academy of Dermatology” This article reviews major types of genetic hair shaft defects and associated syndromes, emphasizing understanding histologic features and diagnostic methods, but reports no new clinical findings.
45 citations
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February 2018 in “Journal of basic and clinical physiology and pharmacology/Journal of basic & clinical physiology & pharmacology” This review summarizes the ethno-medicinal uses, phytochemical constituents, and biological activities of Acorus calamus, highlighting its potential therapeutic benefits and the importance of further scientific work on this plant.
42 citations
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March 2006 in “Drug Discovery Today: Therapeutic Strategies” This article discusses the need for rational strategies in developing hair loss drugs targeting specific events in hair follicle cycling, reporting no clinical findings but emphasizing the importance of understanding molecular controls.
42 citations
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February 1998 in “The Journal of Steroid Biochemistry and Molecular Biology” This study found that PNU 157706 is a highly potent inhibitor of human 5α-reductase enzymes, showing a stronger and longer-lasting antiprostatic effect in rats compared to finasteride.
40 citations
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December 2019 in “Neurobiology of Stress” This review focuses on neuroactive steroids' influence on GABA-ergic signaling and discusses challenges in developing them for various therapeutic uses, citing recent excitement from FDA approval of allopregnanolone for postpartum depression but reporting no new results.
19 citations
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December 2016 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics” This study found that multiple ion channel modulators, used here at clinical concentrations, increased intracellular calcium release in prostate and breast cancer cell lines.
8 citations
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September 2022 in “Biointerface Research in Applied Chemistry” This review examines the pharmacological potential of quinoline alkaloids from Cinchona bark for developing new drugs and cosmetics but reports no new findings.
6 citations
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April 2023 in “Frontiers in plant science” In this study, NREs from lentil root nodules, specifically Serratia plymuthica 33GS and Serratia sp. R6, significantly enhanced lentil growth, altered root exudation, and modulated rhizospheric microbial communities in a greenhouse setting.
3 citations
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November 2018 in “Journal of cellular physiology” In laboratory settings, this study suggests that Serenoa repens and N-acetyl glucosamine with milk proteins may promote hair follicle vascularization through specific cellular interactions and actions.
81 citations
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July 2008 in “The Journal of Clinical Endocrinology and Metabolism” This study found that cortisone reductase deficiency is caused by inactivating mutations in the H6PD gene, affecting cortisol metabolism by preventing 11β-HSD1 enzyme function.
2 citations
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March 2024 in “International Journal of experimental research and review” This study found that more than 14% of idiopathic recurrent early pregnancy loss cases were associated with chromosomal heteromorphisms, predominantly 9qh+, suggesting a genetic component in these unexplained cases.
May 2024 in “Frontiers in medicine” In this study, a 3-year-old Japanese child with autosomal recessive woolly hair was found to have a distinctive irregular and rough cuticle on the hair shaft, along with a homozygous pathogenic LIPH variant, suggesting a critical role for genetic analysis in understanding rare hair conditions.
3 citations
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March 2022 in “Haya: the Saudi journal of life sciences” This review discusses the various benefits of date palm, including its use in cardiovascular health, cosmetics, and skin and hair treatments, but reports no new clinical findings.
12 citations
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August 2014 in “Elsevier eBooks” This article discusses thallium absorption, excretion, and its toxic effects on humans and animals, emphasizing the need for monitoring in areas with significant environmental contamination; no new clinical results are reported.
3 citations
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January 2000 This chapter discusses various substances and therapies for dermatological applications, including heliotherapy, UVB, khellin, and others, but reports no new research findings.
1 citations
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March 1954 in “Archives of dermatology” This article reviews small animal experiments reported from 1932 to 1952 in two dermatology journals and notes the contributions of Farris's book on laboratory animal care.
January 2011 in “Side effects of drugs annual” Tretinoin gel is safe for sun exposure, but tacalcitol doesn't significantly improve non-segmental vitiligo.
137 citations
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January 2000 in “Skin Pharmacology and Physiology” This review outlines the factors affecting skin greasiness and sebum production, highlighting measurement challenges but reports no new clinical findings; further research may guide sebosuppressive treatments for acne.
19 citations
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January 2015 in “Current problems in dermatology” This review discusses environmental factors like UV radiation and smoking that affect hair health and highlights the potential role of nutrition, but it reports no new results.
78 citations
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December 2011 in “Clinical toxicology” This study describes a case series of nine patients experiencing symptoms of selenium toxicity after consuming a liquid dietary supplement with an excess amount of selenium.
41 citations
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November 2024 in “Molecular Biomedicine” This review discusses the mechanisms and engineering techniques for enhancing the targeted delivery of extracellular vesicles in therapies but reports no new clinical findings; the authors encourage further exploration to advance clinical applications.
40 citations
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August 2018 in “Skin appendage disorders” This review examines complementary and alternative medicine for alopecia and finds limited support from robust clinical trials, highlighting the need for standardized studies to evaluate efficacy and safety.