research Antiandrogens
Antiandrogens block male hormones and are not safe during pregnancy.
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research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia
Finasteride effectively treats BPH but may increase sexual dysfunction risk.
research Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition
The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.
research SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder
Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.
research Effects of In Utero Exposure to Finasteride on Androgen-Dependent Reproductive Development in Male Rats
Exposure to finasteride in the womb caused lasting reproductive issues in male rats.
research Finasteride: A Slow-Binding 5-Alpha-Reductase Inhibitor
Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.
research Finasteride in the Treatment of Androgenetic Alopecia
Finasteride effectively treats male pattern baldness, improving hair growth and density.
research Peripheral Androgens And The Role Of Androstanediol Glucuronide
Androstanediol glucuronide is a reliable marker for hirsutism in women.
research Finasteride for Female Androgenetic Alopecia
Finasteride increases hair density in female androgenetic alopecia, but individual results may vary.
research The Effect of Spironolactone on Genital Skin 5α-Reductase Activity
Spironolactone reduces the enzyme activity that converts testosterone to DHT, helping treat excessive hair growth in women.
research Finasteride, a 5alpha-Reductase Inhibitor, Blocks the Anticonvulsant Activity of Progesterone in Mice
Finasteride, a drug, can block the seizure-preventing effects of a hormone called progesterone in mice.
research Inhibition of Rat 5α-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract of Quercus Acutissima Cortex
An extract from Quercus acutissima bark was found to reduce sebum production and block an enzyme linked to acne.
research Minoxidil Increases 17β-Hydroxysteroid Dehydrogenase and 5α-Reductase Activity in Cultured Human Dermal Papilla Cells from Balding Scalp
Minoxidil boosts enzymes that help hair growth.
research Thyroid Hormone Action on Skin
Thyroid hormones are important for skin health and might help treat skin diseases, but more research is needed to understand their effects fully.
research The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but Not for Maintenance of the Epidermal Stem Cell Compartment
Vitamin D Receptor is needed for hair growth in mice but not for skin stem cell maintenance.
research Ovarian Hormones and Adrenal Androgens During a Woman's Life Span
Women's ovarian hormones and adrenal androgens change throughout life, affecting hair loss and health.
research Evaluation of New Pregnane Derivatives as 5α-Reductase Inhibitors
New pregnane derivatives are effective at inhibiting an enzyme linked to hair loss and reducing oil gland activity.
research Management of Neonates and Children with Male Pseudohermaphroditism
Individuals with male pseudohermaphroditism often do better raised as females with early surgery.
research XEDAR Activates the Non-Canonical NF-κB Pathway
XEDAR triggers a specific signaling pathway in cells.
research Synthesis and Pharmacological Evaluation of New 16-Methyl Pregnane Derivatives
New pregnane derivatives were more effective than finasteride at inhibiting a key enzyme for male pattern baldness.
research Intracrine Testosterone Activation in Human Pancreatic Beta-Cells Stimulates Insulin Secretion
Testosterone helps human pancreatic cells increase insulin release.
research Aromatase Inhibition by Letrozole Attenuates Kainic Acid-Induced Seizures but Not Neurotoxicity in Mice
Letrozole reduces seizures but not brain damage in mice.
research Effect of Petroleum Ether and Ethanol Fractions of Seeds of Abrus Precatorius on Androgenic Alopecia
The seeds of Abrus precatorius, when processed, can prevent hair loss more effectively than common treatments.
research The Effect of Minocycline on the Metabolism of Androgens by Human Oral Periosteal Fibroblasts and Its Inhibition by Finasteride
Minocycline may cause hair loss by increasing DHT levels, but finasteride can help counteract this effect.
research Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes
Prostaglandin D2 increases testosterone production in skin cells through a process involving reactive oxygen species, and antioxidants may help treat hair loss.
research Promotion of Hair Growth by Newly Synthesized Ceramide Mimetic Compound
A new compound, BOI, can help hair grow by changing hair cycle phases and increasing certain cell contents.
research 11α-Hydroxyprogesterone, a Potent 11β-Hydroxysteroid Dehydrogenase Inhibitor, Is Metabolized by Steroid-5α-Reductase and Cytochrome P450 17α-Hydroxylase/17,20-Lyase to Produce C11α-Derivatives of 21-Deoxycortisol and 11-Hydroxyandrostenedione In Vitro
11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.
research Vitamin D Resistance and Alopecia
Vitamin D is important for more than just bone health.
research Anti-Androgen Therapy in Dermatology: A Review
Anti-androgens are effective for female acne but less so for male-pattern hair loss, with side effects similar to birth control pills.
research Androgenetic Alopecia: Modeling Progression and Regrowth
AGA causes hair loss through follicle miniaturization and hair cycle changes; regrowth depends on anagen initiation in kenogen follicles.