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Kir6.1 mutations in Cantú syndrome increase channel sensitivity and hyperpolarization, while SUR2B mutations do not.

Afatinib, neratinib, and zanubrutinib could be effective against KRASG12C-mutant tumors.

Polish medical societies recommend personalized treatment for PCOS based on the patient's specific symptoms and use the Rotterdam criteria for diagnosis.

Women with PCOS often have more body hair, acne, and skin darkening, and these signs are linked to metabolic issues like insulin resistance and high cholesterol.

Watching, not removing, skin growths with moderate atypia and positive edges is okay; patients may get melanoma elsewhere, especially if they've had it before.

Hydroxychloroquine may cause false results in tuberculosis tests for patients with autoimmune skin diseases.

Drug repositioning is becoming more targeted and efficient with new technologies, offering personalized treatment options and growing interest in the field.

High-dose finasteride may help treat glioblastoma but needs localized delivery for effectiveness.

A new mutation in the TMEM173 gene and a risk allele in IFIH1 cause a unique set of immune-related symptoms.

Certain drugs, especially antiandrogens and spironolactone, significantly increase the risk of gynecomastia.

Hypothyroidism may cause certain types of hair loss.

An imbalanced gut and lack of biotin can cause hair loss in mice.

Men can have genetic risks for PCOS-related traits like obesity and diabetes.

The document concludes that more research is needed to fully understand the causes of PCOS.

Patients with mycosis fungoides have a higher risk of heart disease.

Calcineurin inhibitors, used in kidney transplants, can cause a wide range of side effects including kidney damage and other health issues.

Researchers found genetic mutations causing hypohidrotic ectodermal dysplasia in 88% of studied patients and identified new mutations and genetic variations affecting the disease.

Finasteride for hair loss may cause persistent sexual symptoms, depression, anxiety, and lower quality of life.

Researchers found genes and genetic variants linked to sheep wool and skin wrinkles.

Finasteride reduces Tourette syndrome symptoms, but results may be limited due to potential biases.

Hair transplant surgeons should also focus on their patients' overall health, including regular check-ups and screening for common health issues.

Women with PCOS may take longer to get pregnant but can have a normal family size, and should manage their overall health to reduce long-term health risks.

The LRRK2-G2019S mutation in Parkinson's disease has a lifetime penetrance of 25-35%, and finasteride may help reduce symptoms in adult male Tourette syndrome patients.

The document describes a woman with familial Parkinson's disease due to a genetic mutation, showing severe symptoms and poor response to treatment, and suggests finasteride may help reduce symptoms in Tourette syndrome.

THAP1 gene changes do not affect DYT1 dystonia; finasteride may help reduce tics and OCD in Tourette syndrome.

Diet changes can protect against harmful environmental effects on fetal development.

Finasteride significantly reduced tics and obsessive-compulsive symptoms in Tourette syndrome patients.

Finasteride may help reduce tic severity in male Tourette syndrome patients.

Finasteride significantly reduced tics and obsessive-compulsive symptoms in patients with Tourette syndrome.

Finasteride may help reduce symptoms in male Tourette syndrome patients.