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    Glossary Cochlear Hair Cells

    specialized inner ear cells that convert sound into signals

    Cochlear hair cells are specialized sensory cells located in the cochlea of the inner ear. They play a crucial role in hearing by converting sound vibrations into electrical signals that the brain can interpret. There are two types: inner hair cells, which primarily send auditory information to the brain, and outer hair cells, which amplify and fine-tune sound vibrations. Damage to these cells can lead to hearing loss.

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    Research 30 of 261

    1. Rapamycin but not acarbose decreases age-related loss of outer hair cells in the mouse Cochlea Hearing research · 2018 · 15 citations
    2. Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice International Journal of Molecular Sciences · 2021 · 8 citations
    3. Melatonin Alleviates the Oxygen–Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2 (NFE2L2)/ROS/NLRP3 Pathway Molecular Neurobiology · 2022 · 5 citations
    4. Melatonin protects cochlear hair cells from nicotine‐induced injury through inhibiting apoptosis, inflammation, oxidative stress and endoplasmic reticulum stress Basic & Clinical Pharmacology & Toxicology · 2021 · 5 citations
    5. Inositol hexaphosphate alleviates ototoxicity and age‐related hearing loss by preserving cochlear hair cells in mice British Journal of Pharmacology · 2025
    6. Deferoxamine protects cochlear hair cells and hair cell-like HEI-OC1 cells against tert-butyl hydroperoxide-induced ototoxicity Biochimica et biophysica acta. Molecular basis of disease · 2024
    7. Data_Sheet_1_Disruption of Hars2 in Cochlear Hair Cells Causes Progressive Mitochondrial Dysfunction and Hearing Loss in Mice.docx OPAL (Open@LaTrobe) (La Trobe University) · 2021
    8. Cochlea hair cell rescue after a noise-induced hearing loss using a low level laser therapy (LLLT) 2011
    9. Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea Science Advances · 2022 · 16 citations
    10. Decision letter: A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea 2019
    11. Effect of low level laser therapy on hair cell regeneration following gentamicin induced ototoxicity in postnatal organotypic culture of rat cochlea Proceedings of SPIE · 2010 · 1 citations
    12. Faculty Opinions recommendation of A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2019
    13. Rps14 upregulation promotes inner ear progenitor proliferation and hair cell regeneration in the neonatal mouse cochlea Research Square (Research Square) · 2022
    14. The Hair Cell Analysis Toolbox: A machine learning-based whole cochlea analysis pipeline bioRxiv (Cold Spring Harbor Laboratory) · 2021
    15. Defining the Cellular Environment in the Organ of Corti following Extensive Hair Cell Loss: A Basis for Future Sensory Cell Replacement in the Cochlea PloS one · 2012 · 71 citations
    16. A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea eLife · 2019 · 15 citations
    17. Author response: A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea 2019
    18. Caffeine Induces Autophagy and Apoptosis in Auditory Hair Cells via the SGK1/HIF-1α Pathway Frontiers in Cell and Developmental Biology · 2021 · 5 citations
    19. Estradiol protects hair cells from cisplatin-induced ototoxicity via Nrf2 activation Redox Report · 2023 · 2 citations
    20. Reviewer #2 (Public Review): CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells 2024
    21. Reviewer #1 (Public Review): CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells 2024
    22. Reviewer #3 (Public Review): CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells 2024
    23. The structural and functional aspects of hair cell regeneration in the chick as a result of exposure to intense sound Experimental Neurology · 1992 · 63 citations
    24. Metformin protects against gentamicin-induced hair cell death in vitro but not ototoxicity in vivo Neuroscience Letters · 2014 · 26 citations
    25. A comparative single-cell transcriptomic atlas for diverse populations of vertebrate hair cells bioRxiv (Cold Spring Harbor Laboratory) · 2026
    26. A Low Dose of Rapamycin Promotes Hair Cell Differentiation by Enriching SOX2+ Progenitors in the Neonatal Mouse Inner Ear Organoids. PubMed · 2024
    27. Whole Neonatal Cochlear Explants as an <em>In vitro</em> Model Journal of visualized experiments · 2023 · 1 citations
    28. EGFR signaling is required for regenerative proliferation in the cochlea: Conservation in birds and mammals Developmental Biology · 2012 · 53 citations
    29. Aging Alters Hair Cell Physiological Properties in Mice with Late-Onset Age-Related Hearing Loss. bioRxiv (Cold Spring Harbor Laboratory) · 2025
    30. A locus on distal chromosome 10 (ahl4) affecting age-related hearing loss in A/J mice Neurobiology of aging · 2008 · 62 citations