This study evaluated the stability of multiple active ingredients in TrichoSol™ for use in alopecia treatments, finding varying stability durations at room temperature—up to 180 days for some ingredients—supporting its use as a compounding vehicle in personalized therapies.
July 2025 in “Pakistan Journal of Intensive Care Medicine” In this randomized controlled trial, researchers observed that topical clobetasol propionate 0.05% was significantly more effective than topical tacrolimus 0.1% for treating alopecia areata, with a higher treatment success rate of 74.2% versus 45.2%, suggesting clobetasol as a preferred first-line topical therapy.
49 citations
,
November 2013 in “JAMA dermatology” This study found that topical clobetasol propionate cream was more effective than hydrocortisone cream in reducing hair loss surface area in children with patchy alopecia areata over 24 weeks, with no serious adverse effects.
146 citations
,
July 2003 in “Journal of the American Academy of Dermatology” In this study, clobetasol propionate 0.05% ointment was found to induce hair regrowth in 28.5% of patients with severe alopecia areata under occlusive conditions, though long-term benefit was limited to 17.8%.
3 citations
,
April 2025 in “International Journal of Pharmaceutics” Nanocrystals improve alopecia areata treatment by better targeting hair follicles.
December 2024 in “Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi” This study found that switching patients with alopecia areata unresponsive to topical clobetasol 17 propionate 0.05% to anthralin treatment led to improved treatment success.
November 2014 in “Prescriber” This article presents a case history of hair loss in a 16-year-old girl and provides no new research findings.
1 citations
,
December 2022 in “Life” This review systematically analyzed evidence on treatment options for erosive pustular dermatosis, finding that while potent topical steroids like clobetasol propionate can be effective, recurrence is common, and more robust studies are necessary for stronger recommendations.
13 citations
,
July 2011 in “Journal of Dermatological Treatment” This study found that topical pimecrolimus is as effective as clobetasol propionate for treating alopecia areata, with better tolerability in terms of side effects.
November 2023 in “Pakistan Journal of Health Sciences” This study found that clobetasol propionate 0.05% was significantly more effective in stimulating hair re-growth in alopecia areata patients compared to topical tacrolimus 0.1%, with an excellent response observed in 74.3% of the clobetasol group versus 40% in the tacrolimus group.
January 2026 in “Saudi Journal of Internal Medicine” This narrative review suggests that while corticosteroids and Janus kinase inhibitors may be effective for treating ophiasis-pattern alopecia areata in both adults and children, the limited age-specific evidence underscores the need for further research to confirm their efficacy and safety across age groups.
69 citations
,
December 2015 in “Journal of Controlled Release” This study found that nanocapsules formulated as a dispersion and applied with massage may enhance follicular uptake of clobetasol propionate while minimizing its skin penetration, offering a potential improvement over conventional treatments for scalp diseases.
January 2023 in “Indian Dermatology Online Journal” This study found that there was no significant difference in hair regrowth between clobetasol and bimatoprost for scalp alopecia areata over 12 weeks, but bimatoprost had fewer side effects and prompted earlier, more pigmented hair regrowth.
13 citations
,
November 2012 in “Journal of The European Academy of Dermatology and Venereology” This study found that topical clobetasol propionate cream provided a modest improvement in hair regrowth for alopecia areata patients, though those with atopy had higher relapse rates after treatment completion.
1 citations
,
January 2019 in “Skin appendage disorders” This case report highlights that new onset non-scarring alopecia after allogeneic stem cell transplantation may indicate chronic graft-versus-host disease.
June 2023 in “Journal of chemical metrology” This study used LC-HRMS to detect undeclared pharmaceutical ingredients like minoxidil and finasteride in hair serums, finding risk to public health due to their toxicological properties and advocating for manufacturer transparency.
32 citations
,
January 2005 in “Journal of The American Academy of Dermatology” In this study, all four cases of congenital alopecia areata experienced periods of remission, with clobetasol propionate 0.05% achieving full hair regrowth in half of the patients treated.
53 citations
,
February 2017 in “Journal of The American Academy of Dermatology” In this study of 20 patients with erosive pustular dermatosis of the scalp, using trichoscopy improved diagnosis, and treatments with high-potency steroids or topical tacrolimus effectively reduced inflammatory signs, suggesting these as first-line treatments.
52 citations
,
January 2020 in “Scientific Reports” This study found that nanostructured lipid carriers with clobetasol propionate significantly enhance follicular drug delivery compared to commercial cream, and manual massage further doubles follicular retention.
2 citations
,
January 2009 in “Actas Dermo-Sifiliográficas” This article reviews various treatments for scalp psoriasis, emphasizing the effectiveness and long-term safety of combining potent corticosteroids with vitamin D3 analogues, but reports no new clinical results.
October 2025 in “Iraqi postgraduate medical journal” This study observed that using fractional CO2 laser-assisted delivery of clobetasol propionate cream significantly improved treatment outcomes for localized alopecia areata compared to the cream alone, suggesting the laser's enhancing effect on hair regrowth.
July 2022 in “Al-Mağallaẗ al-ʻirāqiyyaẗ li-l-ṣaydalaẗ” In this study, topical azelaic acid cream 20% was observed to show acceptable efficacy for treating localized alopecia areata of the scalp, offering a potential therapeutic alternative to topical clobetasol ointment 0.05%.
January 2022 in “Open Access Macedonian Journal of Medical Sciences” This case report discusses a 5-year-old boy with alopecia totalis who initially experienced regrowth after treatment with Prosential, minoxidil 2%, and clobetasol propionate 0.05%, but later relapsed.
April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study evaluated current treatments for pediatric alopecia areata and found that high potency topical steroids had the strongest supporting evidence, with promising results also observed for anthralin ointment and other treatments in lower-grade studies.
1 citations
,
April 2022 in “Clinical Cosmetic and Investigational Dermatology” In this study, a case of lichen amyloidosis on the scalp significantly improved with a 2-month topical treatment using clobetasol propionate/all-trans retinoic acid ointment.
2 citations
,
June 2021 in “Sultan Qaboos University medical journal” This case report presents three sisters with familial frontal fibrosing alopecia, making it the 25th documented familial case, with treatment results observed in one sister.
October 2025 in “Archives of Dermatological Research” Topical metformin gel is as effective and safe as steroids for treating alopecia areata.
21 citations
,
May 2017 in “Paediatric drugs” Individualized treatment plans are crucial for children with alopecia areata, with promising options like JAK inhibitors showing significant hair regrowth.
3 citations
,
August 2022 in “JAAD case reports” This review discusses the emerging evidence for low-dose oral minoxidil in treating various types of alopecia, without providing new clinical results.
1 citations
,
December 2017 in “Annals of Dermatological Research” This case report highlights that dermatoscopy and histopathological analysis were crucial for accurately diagnosing Lichen Planopilaris in two patients, leading to a correct diagnosis after initial misdiagnoses.