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Humans lost body hair relatively recently in evolution.

Guidelines for diagnosing common hair loss include detailed history, clinical examination, and various diagnostic techniques.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

The article concludes that the wool follicle is a valuable model for studying tissue interactions and has potential for genetic improvements in wool production.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.

Giving a special protein to dogs with a certain genetic disease improved their symptoms but didn't help with hair growth.

Lowering testosterone speeds up wound healing in male mice.

Thymus transplantation successfully restored immune function in infants with FOXN1 deficiency.

A WNT10A gene mutation leads to ectodermal dysplasia by disrupting cell growth and differentiation.

Researchers identified genes linked to coat color, body size, cashmere production, and high altitude adaptation in goats.

New hormonal contraceptives are safer, have fewer side effects, and offer health benefits for women.

The Foxn1 gene mutation causes hairlessness and immune system issues, and understanding it could lead to hair growth disorder treatments.

Mutant mice help researchers understand hair growth and related genetic factors.

Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.

Animal models have helped understand hair loss from alopecia areata and find new treatments.

Memantine may slightly improve memory in people with Down syndrome, but more research is needed.

Despite progress, better treatments and understanding are needed for the high rates of long-term issues and deaths linked to eating disorders.

Certain mutations in the H6PD gene cause Cortisone Reductase Deficiency by affecting hormone production.

Hidradenitis suppurativa is caused by genetic factors, inflammation, bacteria, hormones, and lifestyle factors like obesity and smoking.

Stress hormone corticosterone blocks a growth factor to slow down hair stem cell activity and hair growth.

Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.

Aromatase gene variation may increase female hair loss risk.

Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.