Foxp3 Post-Translational Modifications and Treg Suppressive Activity
October 2019
in “
Frontiers in Immunology
”
TLDR Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.
The review article from October 2019 examines the importance of regulatory T cells (Tregs) in immune balance and the prevention of autoimmunity, with a focus on the post-translational modifications (PTMs) of the Foxp3 protein, a key regulator of Treg development and function. The document details how PTMs such as phosphorylation, O-GlcNAcylation, acetylation, ubiquitylation, and methylation influence Foxp3 activity and Treg suppressive capabilities. It also explores the phenotypical characteristics of Tregs, their metabolic programs, and the unique aspects of tissue-resident Tregs in various environments. The review suggests that a deeper understanding of Foxp3's features and modulation could contribute to the development of treatments for immune-related diseases and cancer. However, it emphasizes the need for further research to fully comprehend the roles of PTMs in Treg suppression. No specific study population is mentioned as the document is a review of molecular mechanisms rather than a clinical study.
