7 citations
,
October 2024 in “Cells” The researchers reported that autophagy, a lysosome-dependent degradation mechanism, plays a significant role in the cellular remodeling of keratinocyte differentiation in the skin, affecting the properties of the differentiation products by altering cellular components during this process.
5 citations
,
November 2025 in “Cells” This review summarizes the roles of various cells and signaling pathways in skin wound healing, highlights deviations leading to pathological outcomes like chronic wounds, and evaluates cutting-edge approaches such as biomaterials and precision medicine to improve healing and intervention strategies.
4 citations
,
November 2022 in “Journal of clinical and translational research” This systematic review found that chitosan-based wound therapy may accelerate wound healing by reducing inflammation and modulating immune response, but notes limited clinical trials to date.
3 citations
,
December 2023 in “Biomedicines” This review discusses the mechanisms and potential benefits of platelet-rich plasma therapy for various skin conditions and reports no new clinical findings.
3 citations
,
February 2018 in “Vigilância Sanitária em Debate” This review discusses the characteristics and potential clinical applications of platelet-rich plasma in Brazil, emphasizing the need for standardized protocols and regulatory oversight to ensure safety and efficacy.
3 citations
,
February 1983 in “Journal of Investigative Dermatology” This study found that plucking hair from rats' dorsal skin rapidly decreased ornithine decarboxylase activity, possibly due to an inhibitory substance that was activated by ammonium sulfate treatment.
April 2025 in “Annals of Medicine” This study suggests that the key mechanism of stress-related hair loss involves CRH-induced PTEN loss, which reduces autophagy and increases apoptosis in dermal papilla cells, highlighting potential therapeutic targets like PTEN activation or autophagy enhancement.
February 2025 in “International Journal of Biological Macromolecules” This study developed a NIR light-triggered NO-releasing hydrogel that promotes angiogenesis, repairs damaged dermal papilla cells, reduces inflammation, and improves the nutrient supply and follicular environment in animal models, offering a promising treatment strategy for androgenic alopecia.
January 2025 in “Cosmetics” This review highlights the multifunctional role of exosomes in dermatology, noting their potential as therapeutic agents for conditions like skin cancers and hair disorders, while also indicating pathogens exploit them for immune evasion.
April 2019 in “Journal of Investigative Dermatology” This study found that bioelectric and biochemical signaling mechanisms coordinate collective cell movement during chicken feather bud morphogenesis, suggesting a potential new angle for research in skin development and wound healing.
March 2013 in “Molecular & Cellular Toxicology/Molecular & cellular toxicology” In this study, exposure to m-Aminophenol in human keratinocytes altered the expression of thousands of genes involved in inflammation and stress responses, suggesting potential biomarkers for MAP-induced skin toxicity.
December 2018 in “IntechOpen eBooks” This review discusses recent advancements in understanding neuroendocrine regulation of keratin biology and highlights the potential of neurohormones to treat skin disorders, but it reports no new clinical results.
November 2015 in “Journal of the Korea Academia-Industrial cooperation Society” This study established a stable cell line for CRF1 receptor screening, which can be used to develop functional cosmetics and modulators potentially affecting hair re-growth.
24 citations
,
October 2019 in “Biomaterials Research” This study investigated the use of Minoxidil encapsulated in HA-PLGA nanoparticles for alopecia treatment and found that these nanoparticles efficiently delivered the drug to hair follicle cells without significant cytotoxicity, offering a potential transdermal delivery method for various diseases.
908 citations
,
July 2015 in “British Journal of Dermatology” This article reviews the cellular and molecular processes of acute and chronic wound healing, emphasizing the need for collaboration between researchers and clinicians to advance therapeutic solutions; it presents no new clinical results.
326 citations
,
February 2009 in “The American journal of pathology” This review discusses the role of Lgr5 as a marker for identifying adult stem cells, particularly in the intestine and hair follicles, and reports no clinical results.
284 citations
,
May 2002 in “Proceedings of the National Academy of Sciences” In vitro, this study suggests that CRH may act as an autocrine hormone in human sebocytes, influencing lipid synthesis and potentially impacting skin disorders related to alterations in sebaceous lipid formation.
248 citations
,
December 2011 in “Journal of Neuroscience” This study demonstrated that stress-derived neurosteroid THDOC shifts from inhibiting to activating the HPA axis under stress, presenting potential therapeutic targets for stress-related disorders.
211 citations
,
November 2018 in “Nature Cell Biology” This article discusses the coordinated roles of different epidermal stem cells and other cell types in the skin's wound healing process and reports no new experimental results.
126 citations
,
January 2009 in “International Journal of Trichology” This review discusses the potential role of oxidative stress in hair graying and age-related alopecia, emphasizing the need for new strategies to counteract these effects, but reports no new results.
106 citations
,
July 2013 in “Advances in wound care” This review discusses the potential of ultraviolet (UV) radiation technologies in wound care, highlighting their antimicrobial properties and risks of DNA damage, but reports no new clinical findings.
101 citations
,
October 2016 in “Nanomedicine: Nanotechnology, Biology and Medicine” This review reports on the dual aspect of fullerene in skincare, highlighting its beneficial antioxidant properties as well as potential toxicity and skin cell reactions, while identifying areas for future research.
98 citations
,
July 2014 in “Trends in Molecular Medicine” This article discusses the role of human hair follicles in neuroendocrinology and suggests potential new therapeutic targets by examining how neuromediators influence hair growth, pigmentation, and stem cell biology in organ cultures.
89 citations
,
January 2009 in “Advances in Clinical Chemistry” This review discusses the differences in wound healing between fetal and adult skin, highlighting the potential to uncover genes for scarless repair that could improve adult wound healing.
87 citations
,
March 2005 in “Journal of Dermatological Science” This study found that the extract of Asiasari radix may promote hair growth in mice by enhancing protein synthesis, cell proliferation, and growth factor expression.
74 citations
,
May 2016 in “Current opinion in pediatrics, with evaluated MEDLINE/Current opinion in pediatrics” This review identifies shared interferon gamma-driven immune pathways in vitiligo and alopecia areata, revealing potential targets for new treatments, but reports no clinical results.
72 citations
,
December 2012 in “Expert Opinion on Drug Delivery” This review discusses niosomes' increasing popularity in dermatology for topical drug delivery due to their ability to enhance drug penetration, provide sustained release, and carry various drugs, while reporting no new clinical findings.
71 citations
,
January 2019 in “International journal of biological sciences” This study proposes the miR-22-5p-LEF1 axis as a novel pathway that may regulate hair follicle stem cell proliferation.
68 citations
,
September 2018 in “Trends in Cell Biology” This review discusses the senescence–stemness connection in cellular biology and reports no new findings, highlighting implications for both tissue repair and aggressive cancer behavior.
67 citations
,
July 2016 in “Reviews in Endocrine and Metabolic Disorders” This review discusses the complex relationship between stress and various skin conditions, highlighting the role of the skin in the stress response and the brain-skin communication pathways, but reports no new research findings.