224 citations
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March 2006 in “Seminars in Cutaneous Medicine and Surgery” This article discusses the hair follicle's regenerative cycles and the molecular mechanisms influencing them, emphasizing the need for therapeutic targeting of the "hair cycle clock" to manage hair growth disorders, without reporting new research findings.
December 2023 in “Journal of Volgograd State Medical University” This study reviewed current research on white, brown, and beige adipose tissue, highlighting their roles in metabolism, thermogenesis, tissue repair, and stem cell activity, and identified the study of adiponectins as important for advancing knowledge of metabolic syndrome and tissue regeneration mechanisms.
January 2012 in “Human health handbooks” This review examines the various functions of vitamin D and its receptor in regulating skin processes, highlighting their role in cell differentiation, immunity, and tumor suppression, but reports no new clinical results.
This study found that activating autophagy in hair follicle stem cells can promote hair growth by shifting their metabolism to glycolysis, while inhibiting it led to delayed hair cycle progression.
June 2023 in “Research Square (Research Square)” This study found that autophagy activation in hair follicle stem cells shifted their metabolism to glycolysis, which promoted hair growth by initiating the hair follicle cycle.
34 citations
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April 2018 in “EMBO journal” This study found that in mouse skin, the activation of stem/progenitor cells is synchronized across different niches during growth, with the glutamate transporter SLC1A3 playing a crucial role in this process.
1 citations
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October 2013 This chapter discusses stem cell activity in feather and hair follicles, emphasizing how stem cells maintain their population by cycling between quiescence and activation in specialized niches but reports no new results.
1 citations
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December 2023 This study explored the complex developmental processes of human hair, emphasizing the intricate interactions required for hair follicle morphogenesis and its implications for drug incorporation and concentration interpretation, particularly in early childhood.
January 2014 in “Institutional Repositories DataBase (IRDB)” The study observed that cell spheres formed from mesenchymal cells of newborn mice skin exhibited upregulation of markers linked to hair follicle regeneration, suggesting a potential hibernation-like state for maintaining viability.
January 2014 in “Institutional Repositories DataBase (IRDB)” This study found that cell spheres formed from mesenchymal cells in newborn mouse skin showed increased expression of genes associated with hair follicle regeneration, though marker distribution varied and requires further investigation.
3 citations
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September 2022 in “Frontiers in veterinary science” This study identified key genes and signaling pathways involved in cashmere goat hair follicle growth cycles, influenced by melatonin implantation, suggesting a basis for further research on melatonin's regulatory mechanism.
8 citations
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February 2021 in “Biomolecules & therapeutics” This study found that myristoleic acid promotes dermal papilla cell proliferation and anagen signaling through autophagy, cell cycle progression, and activation of the Wnt/β-catenin and ERK pathways.
60 citations
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March 2011 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that RANK-RANKL signaling regulates hair renewal and epidermal homeostasis in mice, revealing its role in initiating hair growth cycles and maintaining skin cell activity.
January 2025 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that rhamnose can restore hair-inducing gene expression in dermal papilla cells and accelerate hair follicle regeneration by promoting the hair cycle into the anagen phase, suggesting its potential therapeutic application for alopecia treatment.
September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, the researchers observed that post-radiation hair follicle repair in 3D architecture occurs through independent, long-range cell movements along the basal surface, resembling 2D healing processes.
84 citations
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July 2003 in “European journal of biochemistry” This study found that mouse skin can produce and metabolize serotonin and N-acetylserotonin, with activity influenced by location, physiological skin status, cell type, and mouse strain.
153 citations
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October 2007 in “Cell Stem Cell” New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.
4 citations
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January 2001 in “Archives of Biochemistry and Biophysics” This study found that TPA induces apoptosis in pig renal epithelial cells by affecting cell cycle proteins, and activated ras can prevent this process.
May 2024 in “BMC veterinary research” In this study, researchers observed that metabolite expression patterns, including sugars, lipids, amino acids, and nucleotides, affect hair follicle growth in cashmere goats, with feeding practices potentially influencing these cycles via hormone and vitamin levels.
1 citations
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May 2024 in “Communications Biology” This study found that Dab2 conditional knockout mice experienced delayed hair follicle cycles and reduced hair follicle stem cell activity, suggesting Dab2's crucial role in regulating stem cell activation and anti-aging process in hair follicles.
October 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that mechanical disruption of the desmosomal cadherin Dsg3 in hair follicle stem cells activates them from quiescence, highlighting its role as a key regulator of stem cell quiescence and epithelial niche integrity.
1 citations
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December 2024 in “BMC Genomics” This study used transcriptome analysis to explore the genetic mechanisms behind the development and seasonal variation of nuptial pads in R. chensinensis, identifying key genes and processes that suggest the pads' development involves complex regulatory pathways, particularly those related to cell cycle and hormone synthesis.
98 citations
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December 2003 in “The FASEB Journal” In this study, thymosin beta4 was found to stimulate hair growth in normal rats and mice by affecting key processes in the hair follicle cycle, such as stem cell migration and extracellular matrix remodeling.
January 2004 in “Giornale di Metafisica: revista bimestrale di filosofia” This study suggests that increased Wnt signaling may promote excessive differentiation of melanocytes, leading to exhaustion of melanocyte stem cells and hair graying in aged mice.
68 citations
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September 2018 in “Trends in Cell Biology” This review discusses the senescence–stemness connection in cellular biology and reports no new findings, highlighting implications for both tissue repair and aggressive cancer behavior.
46 citations
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September 2023 in “Cell Reports” This study reports that sebaceous glands can regenerate after injury through stem cell plasticity, with hair-follicle-derived stem cells replacing sebaceous gland progenitors and playing a crucial role in the regeneration process, which is dependent on FGFR2 signaling and aided by hair growth induction.
142 citations
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June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This workshop overview concluded that follicular epithelial stem cells are multipotent and located in the bulge region of hair follicles, contributing to hair, epidermis, and sebaceous gland formation.
205 citations
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April 2005 in “Journal of Investigative Dermatology” This study describes a system for generating hair follicles from dissociated cells in mice, suggesting that successful development requires a foundational epithelial platform.
April 2024 in “Archiv EuroMedica” This study found that platelet-rich plasma therapy increased hair density in androgenetic alopecia and improved hair regrowth in chronic plaque alopecia, with better results when combined with minoxidil rather than finasteride.
24 citations
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June 1999 in “Mechanisms of Development” This study found that ornithine decarboxylase expression is linked to cell proliferation and differentiation in hair follicle development and growth.