5 citations
,
April 2022 in “Pharmaceutics” This study reported that 5% minoxidil nanoparticles enhanced hair growth more effectively in mice than a commercial minoxidil solution, with significantly higher drug accumulation in the upper hair follicles.
27 citations
,
May 2006 in “Biochemical and Biophysical Research Communications” In this study, Wnt-10b was found to promote hair follicle development and hair growth in cultured mouse embryonic skin and transplanted skin in nude mice.
14 citations
,
July 2021 in “Biomolecules” This study found that Centipeda minima extract promotes hair growth by activating Wnt/β-catenin, ERK, and JNK signaling pathways in human hair follicle dermal papilla cells.
72 citations
,
July 2002 in “Journal of Investigative Dermatology” This study provides genetic evidence that desmoglein-1 can compensate for the loss of desmoglein-3 in hair adhesion, supporting the desmoglein compensation hypothesis.
85 citations
,
September 2013 in “International Journal of Molecular Sciences” This review evaluates existing research on Keratin 15 to assess its validity as a marker for epidermal stem cells, reporting no new results.
19 citations
,
October 2017 in “European Journal of Pharmaceutics and Biopharmaceutics” This study found that the MXD/HP-β-CD GEL formulation promoted greater hair growth and improved gene expression related to hair growth in male rats compared to MXD solution or control groups.
12 citations
,
June 2011 in “Han-guk sikpum gwahakoeji/Han'gug sigpum gwahag hoeji/Han-guk sikpum gwahak hoeji” This study found that MBN, an herbal extract fermented by Lactobacillus plantarum, promoted hair growth and increased related gene expression in C57BL/6 mice.
June 2024 in “Research Square (Research Square)” This study demonstrated that in mice, the absence of Jagged-1 expression in skin-resident regulatory T cells significantly delays wound healing by reducing the accumulation of neutrophils, highlighting the role of Jagged-1 in coordinating immune cell recruitment during injury.
4 citations
,
January 1994 in “Yakugaku zasshi” In this study, EPC-K, a compound with antioxidant and moisturizing effects, was found to decompose significantly under certain conditions, impacting its stability in quasi drug hair-growing products.
22 citations
,
March 2017 in “Scientific reports” This study investigated the role of NLRP3 inflammasomes in alopecia areata and found that outer root sheath cells may contribute to inflammation by increasing IL-1β and HMGB1 secretion when stimulated with double-stranded RNA.
30 citations
,
September 2016 in “Aging Cell” This study found that selenium deficiency in mice accelerated age-related conditions and metabolic decline but unexpectedly promoted longevity, suggesting low selenium levels might separate healthspan and lifespan.
July 2025 in “Dermatologica Sinica” In this study, compound glycyrrhizin promoted hair regrowth in a testosterone-induced alopecia mouse model and increased human hair dermal papilla cell proliferation, likely through activating the Wnt/β-catenin pathway.
August 2015 in “MOJ proteomics & bioinformatics” This study suggests that epithelial-derived pop-up keratinocytes (ePUKs) may improve regenerative medicine applications due to their specific phenotype and increased expression of proteins involved in regulating cellular movement and wound healing.
10 citations
,
August 2022 in “International Journal of Molecular Sciences” This review discusses mechanisms of wound healing impairment in leptin-deficient murine models used for diabetic research, and reports no new clinical results; the authors emphasize the need for further study.
22 citations
,
February 2017 in “Clinical and Experimental Dermatology” This study suggests that icariin promotes hair follicle growth in mice by enhancing IGF-1 expression in dermal papilla cells.
August 2025 in “Frontiers in Pharmacology” In this study, PA-011, a traditional Chinese medicine extract, was shown to improve hair growth in alopecia areata model mice by reducing skin inflammation and altering skin microbiota, indicating its potential therapeutic role for this condition.
1 citations
,
January 2021 in “European Journal of Inflammation” In this study, naringenin and its methylated derivatives reduced depression-like behaviors and inflammation markers in mice exposed to finasteride, suggesting their potential as effective and safe anti-depressive agents.
This study found that enhancing quercetin bioavailability with EubioQuercetin significantly improved external aging signs in mice and influenced gut microbiota and intestinal gene expression, suggesting potential modulation through the gut microbiota–intestinal barrier axis.
5 citations
,
January 2022 in “Molecular Medicine Reports” In this study, topical application of Korean maritime pine bark extract at 2% concentration significantly promoted hair growth in mice, suggesting its potential use for hair loss prevention or treatment.
53 citations
,
April 2021 in “Cell Host & Microbe” This study found that skin microbiota, particularly in wild-type mice, promotes wound-induced hair follicle neogenesis and wound healing, highlighting the potential downsides of routine antibiotic use on skin regeneration.
27 citations
,
August 2006 in “Laboratory Investigation” In this study, the combination of SCF and ET-1 was found to significantly enhance skin pigmentation and melanin content in human skin xenografts on SCID mice compared to either treatment alone.
13 citations
,
January 2015 in “Evidence-based Complementary and Alternative Medicine” This study found that ethanol extracts of Allium tuberosum Rottler ex Spreng significantly promoted hair growth in mice, possibly by increasing IGF-1 expression.
17 citations
,
February 2015 in “International Journal of Molecular Sciences” This study found that keratinocyte stem/progenitor cell-conditioned medium significantly enhanced hair growth in mice and increased the proliferation of human hair follicle cells.
4 citations
,
November 2022 in “Frontiers in endocrinology” This study found that intracrine androgen signaling via 5α-reductase is essential for optimal endometrial decidualization and vascular development during this process in mice.
September 2024 in “Colloids and Surfaces B Biointerfaces” This study found that cedrol nanoemulsions significantly promote hair follicle regeneration and reduce DHT levels in an androgenic alopecia mouse model, suggesting potential efficacy in AGA treatment.
286 citations
,
April 2009 in “The journal of neuroscience/The Journal of neuroscience” This study found that TRPA1-deficient mice exhibited normal cold sensitivity but had decreased mechanical response in nociceptors, suggesting TRPA1's role in mechanotransduction.
12 citations
,
June 2019 in “Psychoneuroendocrinology” This study found that in rodent models, the ability of D1 dopamine receptor activation to impair sensory gating is facilitated by 5α-reductase type 1, which produces allopregnanolone.
August 2024 in “Pharmaceuticals” This study found that oral administration of solubilized sturgeon oil in mice promoted hair growth and positively influenced the gut microbiome associated with hair growth promotion.
9 citations
,
April 2018 in “Canadian Journal of Animal Science” This study found that LEF-1 expression influences dermal papilla cells' proliferation through Wnt signaling, impacting the potential for cashmere yield improvement.
4 citations
,
February 2022 in “Frontiers in molecular biosciences” This study revealed that chronic restraint stress in mice led to significant alterations in metabolic pathways and gene expression associated with hair growth inhibition, using metabolomics and transcriptomics analyses.