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GlossaryCatagen Induction

process triggering hair follicles' transition from growth to regression

Catagen induction refers to the process that triggers the transition of hair follicles from the growth phase (anagen) to the regression phase (catagen). During this phase, hair growth stops, and the hair follicle shrinks and detaches from the dermal papilla, preparing for the resting phase (telogen) before the cycle starts anew. This process is crucial for the natural hair growth cycle and can be influenced by various factors, including hormonal changes and certain medications.

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Roxithromycin Antagonizes Catagen Induction in Murine and Human Hair Follicles: Implication of Topical Roxithromycin as Hair Restoration Reagent

research Roxithromycin Antagonizes Catagen Induction in Murine and Human Hair Follicles: Implication of Topical Roxithromycin as Hair Restoration Reagent

15 citations, September 2008 in “Archives of Dermatological Research”

Roxithromycin, an antibiotic, can increase hair growth and might be used as a treatment for hair loss.

research Inhibitory Effect of Tianeptine on Catagen Induction in Alopecia Areata-Like Lesions Induced by Ultrasonic Wave Stress in Mice

7 citations, April 2013 in “Clinical and Experimental Dermatology”

Tianeptine, an antidepressant, may prevent stress-induced hair loss in mice.

Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways

research Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways

194 citations, March 2003 in “American Journal of Pathology”

Stress stops hair growth in mice by causing early hair growth phase end and harmful inflammation through a specific nerve-related pathway.

Control of Human Hair Growth by Neurotrophins: Brain-Derived Neurotrophic Factor Inhibits Hair Shaft Elongation, Induces Catagen, and Stimulates Follicular Transforming Growth Factor Beta 2 Expression

research Control of Human Hair Growth by Neurotrophins: Brain-Derived Neurotrophic Factor Inhibits Hair Shaft Elongation, Induces Catagen, and Stimulates Follicular Transforming Growth Factor Beta 2 Expression

64 citations, March 2005 in “Journal of Investigative Dermatology”

Brain-Derived Neurotrophic Factor (BDNF) slows down hair growth and promotes hair follicle regression.

research Dopamine Is a Novel, Direct Inducer of Catagen in Human Scalp Hair Follicles In Vitro

19 citations, November 2012 in “British Journal of Dermatology”

Dopamine stops hair growth and pigment production in human scalp hair follicles.

research TGF-β and HSP70 Profiles During Transformation of Yak Hair Follicles from Anagen to Catagen Stage

10 citations, February 2019 in “Journal of cellular physiology”

TGF-β2 helps yak hair follicles enter the regression phase, while HSP70 tries to prevent it.

research Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla

122 citations, November 2010 in “Journal of Dermatological Science”

Male pattern baldness involves hormones and cell signals affecting hair growth.

research Pediculosis

2 citations, June 1980 in “International Journal of Dermatology”

Scalp biopsies are important for diagnosing hair loss conditions.

research Cell-Based Therapy May Be Effective In Alopecia Areata: Preclinical Evidence That Autologous, Peripheral Regulatory γdT Cells Are Preventive In Human Ex Vivo And Therapeutic In Human In Vivo Models

November 2022 in “Journal of Investigative Dermatology”

Cell-based therapy using specific immune cells may help treat alopecia areata by promoting hair regrowth.

research Molecular Biology of Hair Morphogenesis: Development and Cycling

155 citations, August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution”

Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.

Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes

research Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes

57 citations, June 2003 in “American Journal of Physiology-cell Physiology”

Cyclosporin A helps mice grow hair by blocking a specific protein activity in skin cells.

research Canine Noninflammatory Alopecia: A Comprehensive Evaluation of Common and Distinguishing Histological Characteristics

28 citations, May 2012 in “Veterinary Dermatology”

Different types of dog hair loss are linked to problems starting the hair growth phase and early hair cycle ending.

research Regulatory Gamma Delta T Cells Protect Human Scalp Hair Follicles From Alopecia Areata In Vivo

September 2024 in “Journal of the American Academy of Dermatology”

Regulatory γδ T cells help protect hair follicles from alopecia areata and promote hair regrowth.

research A Murine Model for Inducing and Manipulating Hair Follicle Regression: Effects of Dexamethasone and Cyclosporin A

124 citations, August 1994 in “Journal of Investigative Dermatology”

Dexamethasone speeds up hair loss in mice, while cyclosporin A slows it down.

research Panax Ginseng Extract Antagonizes the Effect of DKK-1-Induced Catagen-Like Changes of Hair Follicles

15 citations, August 2017 in “International Journal of Molecular Medicine”

Panax ginseng extract may help prevent hair loss caused by DKK-1.

Mycophenolate Antagonizes IFN-γ-Induced Catagen-Like Changes via β-Catenin Activation in Human Dermal Papilla Cells and Hair Follicles

research Mycophenolate Antagonizes IFN-γ-Induced Catagen-Like Changes via β-Catenin Activation in Human Dermal Papilla Cells and Hair Follicles

11 citations, September 2014 in “International Journal of Molecular Sciences”

Mycophenolate helps reverse hair loss effects caused by IFN-γ by activating a key hair growth pathway.

Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

research Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

92 citations, June 2005 in “Journal of Investigative Dermatology”

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen

research Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen

91 citations, May 2003 in “American Journal of Pathology”

Prolactin affects hair growth cycles and can cause early hair follicle regression.

Protective Effect of Korean Red Ginseng Against Chemotherapeutic Drug-Induced Premature Catagen Development Assessed With Human Hair Follicle Organ Culture Model

research Protective Effect of Korean Red Ginseng Against Chemotherapeutic Drug-Induced Premature Catagen Development Assessed With Human Hair Follicle Organ Culture Model

19 citations, July 2015 in “Journal of Ginseng Research”

Korean Red Ginseng may protect against hair loss caused by chemotherapy.

research Adenosine Promotes Human Hair Growth and Inhibits Catagen Transition In Vitro: Role of the Outer Root Sheath Keratinocytes

3 citations, November 2019 in “Journal of Investigative Dermatology”

Adenosine helps human hair grow and prevents hair loss by targeting specific cells.

research The Epidermal Growth Factor Receptor Decreases Stathmin 1 and Triggers Catagen Entry in the Mouse

10 citations, April 2016 in “Experimental dermatology”

EGFR helps mouse hair follicles stop growing by reducing certain growth regulators.

research An Extract of Leontopodium Alpinum Inhibits Catagen Development Ex Vivo and Increases Hair Density In Vivo

1 citations, May 2022 in “International Journal of Cosmetic Science”

Edelweiss extract can increase hair density and promote hair growth.

research Methods in Hair Research: How to Objectively Distinguish Between Anagen and Catagen in Human Hair Follicle Organ Culture

132 citations, September 2009 in “Experimental Dermatology”

A reliable system was developed to distinguish hair growth stages, aiding in identifying hair growth promoters or inhibitors.

research Do Hair Bulb Melanocytes Undergo Apoptosis During Hair Follicle Regression (Catagen)?

130 citations, December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair follicle melanocytes die during hair regression.

research Principles of Hair Cycle Control

109 citations, December 1998 in “The Journal of Dermatology”

Manipulating the catagen and telogen phases of hair growth could lead to treatments for hair disorders.

research Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen)

43 citations, December 2006 in “The American journal of pathology”

Edar signaling is crucial for controlling hair growth and regression.

research Procyanidin Oligomers Counteract TGF-β1- and TGF-β2-Induced Apoptosis in Hair Epithelial Cells: An Insight into Their Mechanisms

14 citations, January 2006 in “Skin pharmacology and physiology”

Procyanidin compounds from apples and barley promote hair growth and prevent hair cell death.

research Probing the Effects of Stress Mediators on the Human Hair Follicle

159 citations, December 2007 in “American Journal of Pathology”

Stress-related substance P may lead to hair loss and negatively affect hair growth.

Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

research Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

128 citations, March 2006 in “American Journal of Pathology”

Prolactin contributes to hair loss by promoting hair follicle shrinkage and cell death.

research Neurogenic Inflammation in Stress-Induced Termination of Murine Hair Growth Is Promoted by Nerve Growth Factor

108 citations, July 2004 in “American Journal of Pathology”

Stress increases a factor in mice that leads to hair loss, and blocking this factor may prevent it.