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    Did you mean Candidate Genes?
    Glossary Candidate Genes

    specific genes believed to influence a particular trait or disease

    Candidate genes are specific genes that researchers believe may be associated with a particular trait or disease, based on their known biological functions or previous studies. For example, in the context of alopecia (hair loss), scientists might identify candidate genes that are involved in hair growth or immune system regulation, as these processes are relevant to the condition. Identifying and studying these genes can help in understanding the underlying mechanisms of the disease and potentially lead to targeted treatments.

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    1. A conditional multi-trait sequence GWAS discovers pleiotropic candidate genes and variants for sheep wool, skin wrinkle and breech cover traits Genetics selection evolution · 2021 · 11 citations
    2. sc-eQTL unveil Immunogenetic Architecture of Polycystic Ovary Syndrome 2025
    3. MendelVar: gene prioritization at GWAS loci using phenotypic enrichment of Mendelian disease genes bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 2 citations
    4. sc-eQTL unveil immunogenetic architecture of polycystic ovary syndrome Scientific Reports · 2026
    5. Integrated single-cell chromatin and transcriptomic analyses of human scalp reveal etiological insights into genetic risk for hair and skin disease bioRxiv (Cold Spring Harbor Laboratory) · 2022
    6. Large-Scale Plasma Proteomics and Genetic Integration Uncover Novel Biological Pathways in Male Pattern Baldness International Journal of Molecular Sciences · 2026
    7. A mechanism-informed deep neural network enables prioritization of regulators that drive cell state transitions Nature Communications · 2025 · 13 citations
    8. LB1053 Dysregulation of antioxidant enzyme PRDX5 in alopecia areata Journal of Investigative Dermatology · 2019 · 1 citations
    9. Candidate SNP markers of reproductive potential are predicted by a significant change in the affinity of TATA-binding protein for human gene promoters BMC Genomics · 2018 · 16 citations
    10. The Genetics of Seborrheic Dermatitis: A Candidate Gene Approach and Pilot Genome-Wide Association Study Journal of Investigative Dermatology · 2017 · 15 citations
    11. Candidate Gene Analysis Of Alopecia Areata In Jordanian Population Of Arab Descent: A Case–Control Study The application of clinical genetics · 2019 · 6 citations
    12. Genome-wide association study reveals candidate genes associated with body weight and wool traits in Ordos fine-wool sheep Frontiers in Veterinary Science · 2026
    13. Whole genome sequencing analysis of alpaca suggests TRPV3 as a candidate gene for the suri phenotype BMC genomics · 2024
    14. Genome-wide association study for cashmere traits in Inner Mongolia cashmere goat population reveals new candidate genes and haplotypes BMC Genomics · 2024 · 13 citations
    15. Ancient Genomes Reveal the Evolutionary History and Origin of Cashmere-Producing Goats in China Molecular Biology and Evolution · 2020 · 27 citations
    16. A new locus for hereditary hypotrichosis simplex maps to chromosome 13q12.12∼12.3 in a Chinese family Journal of Cutaneous Pathology · 2010 · 7 citations
    17. Exploring the Causal Relationship and Molecular Mechanisms Between Fasting Insulin and Androgenetic Alopecia: A Mendelian Randomization Study with Bioinformatics Analysis Clinical Cosmetic and Investigational Dermatology · 2025
    18. Prioritizing susceptibility genes for the prognosis of male-pattern baldness with transcriptome-wide association study Human genomics · 2024
    19. Whole Genome Scan and Selection Signatures for Climate Adaption in Yanbian Cattle Frontiers in genetics · 2020 · 26 citations
    20. Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia American Journal of Human Genetics · 2005 · 195 citations
    21. Identifying causal genes in alopecia areata using integrative analysis of differential expression and Mendelian randomization 2024
    22. Utilizing functional genomics approaches to characterize risk genes in alopecia areata Columbia Academic Commons (Columbia University) · 2020
    23. Identifying molecular targets for reverse aging using integrated network analysis of transcriptomic and epigenomic changes during aging Scientific Reports · 2021 · 12 citations
    24. Mendelian randomization study highlights hypothyroidism as a causal determinant of alopecia areata Frontiers in endocrinology · 2024
    25. Resequencing and Signatures of Selective Scans Point to Candidate Genetic Variants for Hair Length Traits in Long-Haired and Normal-Haired Tianzhu White Yak Frontiers in Genetics · 2022 · 7 citations
    26. GBP1 as a machine learning-prioritized biomarker and therapeutic target for epstein-barr virus-induced clear cell renal cell carcinoma: multi-omics causal validation International Journal of Surgery · 2025
    27. Multi-omics analyses, cell experiments, and network pharmacology tools identified key proteins and candidate drugs for alopecia areata treatment Clinical Proteomics · 2025
    28. A comparison of transcriptomic patterns measured in the skin of Chinese fine and coarse wool sheep breeds Scientific reports · 2017 · 17 citations
    29. Genomic and Transcriptomic Characterization of Atypical Recurrent Flank Alopecia in the Cesky Fousek Genes · 2022 · 2 citations
    30. Progressive Hair Loss and Myocardial Degeneration in Rough Coat Mice: Reduced Lysyl Oxidase-Like (LOXL) in the Skin and Heart Journal of Investigative Dermatology · 2004 · 22 citations