Resequencing and Signatures of Selective Scans Point to Candidate Genetic Variants for Hair Length Traits in Long-Haired and Normal-Haired Tianzhu White Yak

March 2022 in “ Frontiers in Genetics ”

Qi Bao, Xiaoming Ma, Jia Chen, Xiaoyun Wu, Yi Wu, Guangyao Meng, Pengjia Bao, Min Chen, Xian Guo, Chunnian Liang, Ping Yan

FGF5 CFAP299 ATP8A1 SLC30A9 SHISA3 TMEM33 ACOXL PDPK1 MAGEL2 CDH1 hair follicle development SNPs Single Nucleotide Polymorphisms fibroblast growth factor 5 single nucleotide polymorphisms

Studysummary This study identified genetic loci and pathways associated with long hair growth in the Tianzhu white yak, providing new insights into the genetic mechanisms of this trait. Our plain-language summary of this paper — not a Tressless recommendation.

The research paper studied genetic variants influencing hair length in Tianzhu White Yak, using resequencing of the whole genome of 20 yaks (10 long-haired and 10 normal-haired). The study identified significant genetic differences between the two groups, pointing to specific genes and pathways that may be responsible for hair length variation. Two hotspots on chromosome 6 were found, annotating six genes (FGF5, CFAP299, ATP8A1, SLC30A9, SHISA3, TMEM33). Four genes (ACOXL, PDPK1, MAGEL2, CDH1) were associated with hair follicle development. The study also identified 15,124,083 SNPs (Single Nucleotide Polymorphisms) in the long-haired population and 15,331,905 SNPs in the normal-haired population. These findings could potentially be applied to understanding hair growth and loss in other species, including humans.

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