Dysregulation of Antioxidant Enzyme PRDX5 in Alopecia Areata

    August 2019 in “ Journal of Investigative Dermatology ”
    A.R. Abdelaziz, Md. Mohsin Mian, S. Erjavec, Sahar Gelfman, Pinpin Lin, Iuliana Ionita‐Laza, Lynn Petukhova, Angela M. Christiano
    TLDR PRDX5 enzyme may contribute to alopecia areata by affecting oxidative stress and autoimmunity.
    The study identified peroxiredoxin 5 (PRDX5) as a candidate susceptibility gene for alopecia areata (AA) through genome-wide association studies and exome sequencing of 897 individuals. PRDX5, an antioxidant enzyme, was found to be upregulated in AA-affected hair follicles, suggesting its role in regulating oxidative stress. A significant variant, rs574087, was identified as a likely causal variant in keratinocytes and melanocytes. The research proposed that dysregulation of PRDX5 could lead to autoimmunity, establishing a connection between PRDX5 and AA pathogenesis, and providing a basis for further investigation into its role in the disease.
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