Sc-eQTL Unveil Immunogenetic Architecture of Polycystic Ovary Syndrome
October 2025
polycystic ovary syndrome PCOS genome-wide association study single-cell expression quantitative trait loci sc-eQTL immune cells risk loci candidate causal genes T cell-mediated responses single-cell RNA sequencing NK cells CD8 T cells CD4 T cells IRF1 MAPRE1 metabolic genes immune-related genes T cells
Studysummary This study identified 19 genetic risk loci and 16 potential causal genes related to PCOS, highlighting the role of immune cell-specific mechanisms in its pathogenesis.
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