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research Androgenetic alopecia: Identification of four genetic risk loci and evidence for the contribution of WNT signaling to its etiology

January 2013 in “Faculty of Health; Institute of Health and Biomedical Innovation”

This study aimed to identify unknown genetic risk loci associated with androgenetic alopecia by examining SNPs at 12 genomic loci but did not find complete heritable risk factors.

research Androgenetic Alopecia: Identification of Four Genetic Risk Loci and Evidence for the Contribution of WNT Signaling to Its Etiology

74 citations , January 2013 in “Journal of Investigative Dermatology”

Four genetic risk spots found for hair loss, with WNT signaling involved and a link to curly hair.

research Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness

64 citations , March 2017 in “Nature communications”

This study identified 63 genetic loci associated with male-pattern baldness, uncovering genes and pathways that may help develop treatments and suggesting its connection to other human conditions.

research GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk

57 citations , November 2017 in “Nature Communications”

This genome-wide association study identified 71 genetic loci linked to male pattern baldness, with 30 novel loci, explaining 38% of the risk and suggesting shared pathways with lifespan and cancer traits.

research Genome-wide meta-analysis identifies novel loci conferring risk of acne vulgaris

29 citations , March 2023 in “European Journal of Human Genetics”

This study identified four new genetic loci associated with acne risk and highlighted key pathways involved in its genetic predisposition, potentially explaining 9.4% of acne's phenotypic variance.

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community Dermatologist told me to quit fin after turning 40

in Finasteride/Dutasteride 194 upvotes 2 years ago

A dermatologist advised a patient to stop taking finasteride (fin) after turning 40 due to potential risk of aggressive prostate cancer. The patient and others in the conversation debated this advice, discussing the relationship between finasteride, prostate cancer, and hair loss, and considering alternatives like topical finasteride.

community Tried my best to learn the genetics of male pattern balding

2 upvotes 3 months ago

Male pattern balding is influenced by genetic mutations on several chromosomes, affecting DHT sensitivity, hair pattern, and follicle resilience. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Evidenced Based Meta-Analyses and Systemic Reviews of Androgenic Alopecia and Treatments

14 upvotes 6 years ago

Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.

community I don’t think my hair loss is caused by DHT – quitting finasteride after 3 months (1 mg). Need opinions

6 months ago

The user plans to stop finasteride after three months, believing hair loss isn't due to DHT, and will continue with oral minoxidil, microneedling, and ketoconazole shampoo. They suspect stress and poor nutrition are the main causes and seek opinions on DHT blockers' effectiveness.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

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Learn

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learn Scalp Micropigmentation

Is there a risk of infection with scalp micropigmentation? Scalp micropigmentation has a risk of infection, but proper aftercare minimizes it.

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