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Glossary Candidate Genes

specific genes believed to influence a particular trait or disease

Candidate genes are specific genes that researchers believe may be associated with a particular trait or disease, based on their known biological functions or previous studies. For example, in the context of alopecia (hair loss), scientists might identify candidate genes that are involved in hair growth or immune system regulation, as these processes are relevant to the condition. Identifying and studying these genes can help in understanding the underlying mechanisms of the disease and potentially lead to targeted treatments.

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Research

5 / 1000+ results

research A conditional multi-trait sequence GWAS discovers pleiotropic candidate genes and variants for sheep wool, skin wrinkle and breech cover traits

11 citations , July 2021 in “Genetics selection evolution”

This study used whole-genome sequence data to identify numerous putative causal variants and genes affecting key wool traits and skin wrinkle in Merino sheep, highlighting their polygenic and pleiotropic nature.

research sc-eQTL unveil Immunogenetic Architecture of Polycystic Ovary Syndrome

October 2025

This study identified 19 genetic risk loci and 16 potential causal genes related to PCOS, highlighting the role of immune cell-specific mechanisms in its pathogenesis.

research MendelVar: gene prioritization at GWAS loci using phenotypic enrichment of Mendelian disease genes

2 citations , April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

This article discusses the MendelVar webserver, which integrates Mendelian disease data with GWAS findings to prioritize candidate genes for complex traits and reports no new experimental results.

research sc-eQTL unveil immunogenetic architecture of polycystic ovary syndrome

January 2026 in “Scientific Reports”

In this study, researchers identified 19 genetic risk loci and highlighted 16 candidate causal genes, including immune-related ones, associated with polycystic ovary syndrome, emphasizing the role of specific immune cells like T cells and NK cells in its pathogenesis.

Integrated Single-Cell Chromatin and Transcriptomic Analyses of Human Scalp Reveal Etiological Insights Into Genetic Risk for Hair and Skin Disease

research Integrated single-cell chromatin and transcriptomic analyses of human scalp reveal etiological insights into genetic risk for hair and skin disease

September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study identifies gene-regulatory networks related to genetic variants in skin and hair diseases, suggesting that dermal papilla cells are crucial in androgenetic alopecia.

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community Temporalis Hypertrophy and hair loss

in Treatment 24 upvotes 1 year ago

Hair loss treatments include finasteride, minoxidil, and scalp exercises. Opinions vary on the effectiveness, with some attributing hair loss to muscle tension and inflammation, while others focus on genetics and DHT.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001).

297 upvotes 2 years ago

Sugary beverages increase the risk of pattern hair loss in men by 57%, and type 2 diabetes is linked to female pattern hair loss. Reducing sugar intake and using treatments like finasteride and minoxidil may help manage hair loss.

community We should actually be hopeful for these recent new developments

112 upvotes 1 year ago

AI advancements, like AlphaFold, are speeding up drug discovery for hair loss, promising more effective treatments. Current options like minoxidil and finasteride have limitations, but new developments could improve solutions in 5-10 years.

community Petition: Make PP405 available tomorrow instead of 2030

331 upvotes 1 year ago

PP405, a promising hair loss treatment, is expected to be available by 2027, with faster trials due to its topical nature. Users are eager for its release, comparing it to existing treatments like minoxidil and finasteride, but remain cautious about its long-term effectiveness.

community You don't know what you have until it's gone - Wish I started treatment earlier to save my crown

in Update 270 upvotes 1 year ago

A user regrets not starting finasteride earlier for hair loss, noticing significant crown thinning by age 30. They have started using finasteride and are considering minoxidil for better hair regrowth.

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Experts

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Hair System Specialist
Jane Genesi
Marlton, PA, United States

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Jane Genesi