Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review describes the toxicities associated with calcineurin inhibitors, used in kidney transplantation, which include nephrotoxicity, cardiovascular and endocrine issues, and quality of life impacts, without reporting new clinical results.

This study found that cyclosporin A treatment enhances hair growth in mice by inhibiting calcineurin-NFAT1 activity, which alters keratinocyte differentiation and apoptosis-related gene expression in hair follicles.

The researchers reported that in mice, prolactin signaling in the skin epithelium inhibits hair follicle stem cell activation, promoting quiescence during periods of high serum prolactin like pregnancy and lactation.

This study reports that a German Shepherd developed generalized calcinosis cutis following a presumed bacterial infection, representing the first known case linked to such an infection in adult dogs.

The authors concluded that incorporating routine endocrinology consultations into transplant care could address CNI-related endocrine toxicities, but prospective studies are needed to assess the impact on graft and patient survival.

In this case report, a 15-year-old golden retriever with calcinosis cutis showed accelerated improvement in FLE-treated skin infections compared to untreated areas, highlighting FLE's potential as a treatment adjunct.

This study proposed a hypothesis for cutaneous calcinosis, suggesting that feeding DHT and subsequent epilation lead to ATP release and calcium orthophosphate formation, initiating calcification in rats.

In this case report, a 40-year-old woman with systemic lupus erythematosus developed calcinosis cutis, a rare complication characterized by calcified deposits in her legs, requiring surgical intervention and ongoing medical treatment due to infection.

Early intervention is important for limited systemic sclerosis patients due to higher pain and ulceration risks.

This study discusses calcinosis cutis and alopecia totalis, highlighting the need for thyroid disease screening in children with alopecia areata, especially those with a history of Down syndrome or signs of potential thyroid dysfunction.

This study suggests that the CsA-induced inactivation of the CaN/NFAT pathway may suppress TGF-β2 expression in dermal papilla cells, potentially contributing to CsA-associated hypertrichosis.

This case study reported that reducing glucocorticoids resolved calcinosis cutis in a dog with hypoadrenocorticism, while demodicosis was treated with a fluralaner chewable tablet.

This review discusses the calcineurin/NFAT pathway's role in cutaneous squamous cell carcinoma, noting its involvement in tumor development, skin cell behavior, and the tumor microenvironment; it reports no new results.

This review discusses cyclosporine A's mechanisms of action and side effects compared to tacrolimus in renal transplantation, but it reports no new experimental results; the authors highlight implications for cardiovascular risk management.

This report describes almost complete resolution of calcinosis and healing of associated ulcers in an 83-year-old woman with localized scleroderma after repeated intralesional steroid injections.

This review discusses topical calcineurin inhibitors for cutaneous lupus erythematosus and reports no new clinical findings; the authors emphasize the need for more comparative studies with corticosteroids.

This study found that localized skin calcification could be induced in adult rats through dihydrotachysterol treatment combined with topical trauma, offering an experimental model for calcifying scleroderma.

This commentary discusses whether topical steroids or topical calcineurin inhibitors are better for treating scalp atrophy caused by steroid use in patients with scarring alopecia, but specific results or conclusions are not provided.

This historical observation found that parathyroid extract treatment in newborn rats led to a condition resembling scleroderma, characterized by skin hardening, calcium deposition, and possible necrosis.

In this study, an 8-year-old girl with dermatomyositis and extensive calcinosis showed complete clearance of calcinosis and good disease control after treatment with a combination of corticosteroids, methotrexate, hydroxychloroquine, pamidronate, and intravenous immunoglobulin.

This study demonstrated that phosphatidylcholine liposomes can deliver calcein and melanin into hair follicles and shafts in mice without significant penetration into the dermis, epidermis, or bloodstream.

This review discusses the regulation of the MiT-TFE family transcription factors, particularly TFEB, through phosphorylation-mediated subcellular localization and reports no new clinical results.

This updated guideline from the British Association of Dermatologists discusses current recommendations for managing alopecia areata but reports no new clinical research findings.

This review discusses current treatment challenges and strategies for managing psoriasis in the scalp, nails, and intertriginous areas, emphasizing the need for effective and well-tolerated long-term options, but reports no new clinical results.

This article discusses a new global consensus on the classification of vitiligo, describing histopathological findings and outlining treatment strategies, but reports no new clinical results.

Most dermatologic medications are safe during pregnancy and breastfeeding, but some should be avoided due to potential risks.

Oral dutasteride and topical pimecrolimus can safely and effectively treat Frontal Fibrosing Alopecia, leading to significant hair regrowth.

These guidelines review the management of complications and specific forms of congenital ichthyosis and report no new results; they summarize expert and evidence-based recommendations for clinicians.

This review discusses the potential causes and treatments for frontal fibrosing alopecia but reports no new clinical findings, highlighting the need for further research to understand its pathogenesis and develop validated treatments.