Endocrine Effects of Long-Term Calcineurin Inhibitor Use in Solid Organ Transplant Recipients

Long-term use of calcineurin inhibitors (CNIs) in solid organ transplant recipients is associated with common endocrine toxicities that are modifiable. The document suggests that routine involvement of a multidisciplinary endocrinology team should become a standard part of transplant care to address these issues. It also recommends conducting prospective registry studies to validate the proposed algorithms and to quantify the long-term benefits for both graft and patient survival.