Combination Therapy for Extensive Tumoral Calcinosis in Juvenile Dermatomyositis

An 8-year-old girl with juvenile dermatomyositis and extensive tumoral calcinosis was successfully treated with a combination of high-dose corticosteroids, oral methotrexate, hydroxychloroquine, intravenous vancomycin, pamidronate, and monthly intravenous immunoglobulin. Over the course of a year, this multi-drug regimen resulted in complete clearance of calcinosis and effective disease control without signs of myositis. This case demonstrates the potential effectiveness of combination therapy in resolving extensive calcinosis associated with juvenile dermatomyositis.