Combination Therapy for Extensive Tumoral Calcinosis in Juvenile Dermatomyositis

An 8-year-old girl with juvenile dermatomyositis and extensive tumoral calcinosis showed significant improvement after a combination therapy. Initially presenting with muscle weakness, scalp alopecia, and calcifications, she was treated with high-dose corticosteroids, methotrexate, hydroxychloroquine, and intravenous vancomycin for recurrent cellulitis. Additionally, she received Pamidronate infusions and monthly intravenous immunoglobulin. After one year, there was complete clearance of calcinosis and effective disease control, suggesting that a multi-drug regimen can successfully resolve extensive calcinosis in such cases.