53 citations,
June 2017 in “Skin appendage disorders” PRP treatment helps hair growth in most cases, but more research needed.
14 citations,
February 2020 in “Scientific reports” Telocytes in the scalp may help with skin regeneration and maintenance.
39 citations,
January 2015 in “International journal for parasitology/International Journal for Parasitology” Epidermal keratinocytes start wound healing and inflammation after schistosome infection.
Integrin alphavbeta6 is important for wound healing and hair growth, and blocking it may improve these processes.
9 citations,
September 2013 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry” Matriptase is highly active in hair follicles and sebaceous glands, especially during hair growth phases.
20 citations,
December 2010 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” Decreased CD200 in hair follicles may cause immune issues in some alopecia areata cases.
21 citations,
July 2006 in “Veterinary dermatology” CD34 marks potential stem cells in dog hair follicles.
13 citations,
December 2014 in “Stem Cells” Hair and skin can regenerate without bulge stem cells due to other compensating cells.
27 citations,
January 2006 in “Colloids and Surfaces B: Biointerfaces” Researchers found that bulge cells from human hair can grow quickly in culture and have properties of hair follicle stem cells, which could be useful for skin treatments.
23 citations,
July 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair follicle bulge cells don't help skin regrow after glucocorticoid damage; interfollicular epidermis cells do.
19 citations,
September 2019 in “EMBO molecular medicine” Blocking TSLP reduces skin inflammation and cell overgrowth in psoriasis.
3 citations,
August 2014 in “Cellular reprogramming” Hair follicle stem cells need all reprogramming factors to become pluripotent.
1 citations,
April 2018 in “Journal of Investigative Dermatology” Lower proximal cup cells, not bulge stem cells, regenerate hair follicles after chemotherapy.
36 citations,
April 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Canine hair follicles have stem cells similar to human hair follicles, useful for studying hair disorders.
11 citations,
January 2013 in “Veterinary dermatology” Keratinocytes from dog hair follicles can create a functional skin layer in a lab model, useful for dog skin therapy.
4 citations,
January 2018 in “Microscopy research” Scientists found markers called CD34 and CD200 that help identify stem cells in mouse and human hair follicles.
November 2013 in “Elsevier eBooks” Skin and hair renewal is maintained by both fast and slow cycling stem cells, with hair regrowth primarily driven by specific stem cells in the hair follicle bulge. These cells can also help heal wounds and potentially treat hair loss.
17 citations,
June 2019 in “The journal of immunology/The Journal of immunology” A specific DNA region is crucial for Foxn1 gene expression in thymus cells but not in hair follicles.
4 citations,
January 2021 in “Cell transplantation” Scientists found the best time to transplant human stem cells for hair growth is between days 16-18 when they have the right markers and growth potential.
43 citations,
February 2008 in “Journal of cutaneous pathology” Melanocyte precursors in human fetal skin follow a specific migration pattern and some remain in the skin's deeper layers.
14 citations,
January 2018 in “Scientific reports” Bioluminescence imaging can track hair follicle cells and help study hair regrowth.
1039 citations,
February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
60 citations,
March 2011 in “Proceedings of the National Academy of Sciences of the United States of America” RANK-RANKL signaling is essential for hair growth and skin health.
43 citations,
December 2008 in “Molecular biology of the cell” Disrupting Smad4 in mouse skin causes early hair follicle stem cell activity that leads to their eventual depletion.
10 citations,
December 2011 in “Cell Transplantation” Researchers successfully grew human hair follicle cells that could potentially lead to new hair loss treatments.
66 citations,
March 2019 in “Cellular and Molecular Life Sciences” Melanocyte development from neural crest cells is complex and influenced by many factors, and better understanding could help treat skin disorders.
23 citations,
March 2010 in “Medical hypotheses” Merkel cells may have roles in sensing magnetic fields, creating fingerprints, Reiki energy healing, passing on environmental information to offspring, and influencing hair shape.
9 citations,
November 2018 in “Drug Discovery Today” Using skin stem cells and certain molecules might lead to scar-free skin healing.
17 citations,
January 2014 in “Stem Cells Translational Medicine” Canine epidermal neural crest stem cells could be a promising treatment for spinal cord injuries in dogs.
396 citations,
May 2011 in “Cell stem cell” Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.