Lower Proximal Cup Cells But Not Bulge Stem Cells Regenerate Hair Follicles After Chemotherapy Injury

April 2018 in “ Journal of Investigative Dermatology ”

Wen‐Yen Huang, Jin‐Bon Hong, Michael Chang, C. Chen, Sung‐Jan Lin

chemotherapy hair follicles basal lower proximal cup cells bulge stem cells hair matrix concentric layers regenerative capability stem cells

TLDR Lower proximal cup cells, not bulge stem cells, regenerate hair follicles after chemotherapy.

The study demonstrated that after chemotherapy-induced injury in mice, basal lower proximal cup cells, rather than bulge stem cells, were responsible for regenerating hair follicles. These cells, which did not show conventional stem cell markers and were immotile under normal conditions, became actively motile and repaired damaged hair bulbs by regenerating the hair matrix and all concentric layers of hair follicles. Bulge stem cells remained inactive and did not participate in the regeneration process. This finding highlighted the plasticity and regenerative capability of basal lower proximal cup cells in response to chemotherapeutic damage.

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