December 2022 in “Revista Medicina Cutánea Ibero-Latino-Americana” This review summarizes current knowledge on the role of the JAK/STAT signaling pathway in alopecia areata and suggests moderate efficacy of systemic inhibitors, with low adverse events but high recurrence rates.
November 2020 in “Journal of The American Academy of Dermatology” This study investigated the use of spironolactone in patients with estrogen-dependent cancers, aiming to determine if it is linked to increased cancer recurrence risk, but results are not reported.
January 2014 in “Revista del Hospital Juárez de México” The authors concluded that preoperative treatment with finasteride for a month effectively reduced perioperative bleeding and shortened hospital stays in patients undergoing transurethral resection of the prostate.
March 2020 in “Journal of Laser Applications” This meta-analysis reported that photobiomodulation therapy may improve hair density and stimulate hair growth in patients with androgenic alopecia compared to sham treatments, but larger studies are needed to confirm these findings.
19 citations
,
August 2022 in “Forensic Science International Genetics” This study developed and validated tissue-specific and age prediction models using epigenetic markers, achieving up to 83.69% correct classification for tissue origin and a median absolute error of ±3.66 years for age estimation.
29 citations
,
March 2008 in “Dermatologic Surgery” This study developed a prototype device that suggests potential for diagnosing changes in hair quantity, diameter, and density, though formal clinical studies are needed to confirm these findings.
3 citations
,
November 2022 in “European Journal of Human Genetics” This study developed new genetic prediction models for male pattern baldness with improved accuracy by utilizing a large set of markers and independent datasets, making them the most reliable available for this trait.
September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that hair follicles and urine cell pellets from noninvasive samples may be the most promising for transcriptomic analyses due to their consistent quality and applicability to disease-relevant research.
August 2026 in “Frontiers in Medicine” This article argues that esthetic dermatology could benefit from a more biologically informed approach through the integration of advanced biomarkers and imaging technologies, but cautions that many tools are not yet fully validated for clinical use.
8 citations
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January 2013 in “International Journal of Trichology” This study found that the BASP classification is an effective and easily remembered method for diagnosing and treating male and female pattern hair loss in the Indian population.
In this study, researchers in Baghdad, Iraq found that men with hair loss had higher body fat mass and haematocrit values, and lower blood pressure compared to men without hair loss, suggesting potential links between metabolic and hematologic changes and baldness.
This review explores the evaluation methods and biological parameters involved in hair growth assessment, highlighting their distinct applications and advantages, but presents no new clinical findings.
278 citations
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March 2013 in “Gut” In this study, nearly 5% of anti-TNF-treated patients with IBD developed psoriasiform skin lesions, with smoking identified as a main risk factor, and ustekinumab proved highly effective in severe cases.
211 citations
,
October 2001 in “The FASEB Journal” This study found that the BMP antagonist noggin induces hair growth in postnatal skin by neutralizing BMP4's inhibitory activity, potentially mediated by changes in Shh expression.
210 citations
,
November 2015 in “The Lancet HIV” This study observed that while PrEP was effective among transgender women if taken, adherence was low, especially among those at higher risk.
196 citations
,
May 2001 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that SZ95 sebocytes and HaCaT keratinocytes exhibit distinct enzyme expressions and activities, implicating their different roles in androgen metabolism and homeostasis in vitro.
174 citations
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April 2005 in “The American journal of pathology (Print)” This study found that TRPV1 activation in human scalp hair follicles inhibited hair shaft elongation, suppressed proliferation, and induced apoptosis, suggesting TRPV1 as a potential target for managing hair growth and epithelial disorders.
128 citations
,
March 2006 in “American Journal of Pathology” The study found that prolactin expressed in human scalp hair follicles acts as an autocrine modulator, inhibiting hair growth and promoting hair follicle regression, which may contribute to hair loss in hyper-prolactinemia patients.
96 citations
,
October 2000 in “The FASEB Journal” In this study, researchers found that p75 neurotrophin receptor signaling affects apoptosis during hair follicle regression in mice, and altering its activity might help manage disorders involving early catagen entry.
68 citations
,
December 2014 in “Cell Biochemistry and Function” This review examines the role of nuclear hormone receptors in skin wound repair processes and reports no new clinical results, highlighting the importance of their interaction with skin cells for effective healing.
57 citations
,
August 2003 in “British Journal of Dermatology” This study found that daily use of 1% pyrithione zinc shampoo modestly improved hair growth over 26 weeks, although these effects were less than those of 5% minoxidil.
51 citations
,
November 2013 in “Drug Discovery Today” This review discusses the potential applications and challenges of small molecules in regenerative medicine, but it reports no new research findings.
39 citations
,
December 2013 in “Phytotherapy Research” This study found that hydroxysafflor yellow A-rich Carthamus tinctorius extract promoted hair growth and gene expression linked to hair proliferation in both cell cultures and mouse models.
34 citations
,
June 1990 in “British Journal of Dermatology” This study found that etretinate treatment led to an increase in plucked telogen hair counts, suggesting a reduction in the duration of anagen as the primary cause.
25 citations
,
July 2013 in “Journal of Dermatological Science” This study suggests that the androgen receptor locus on the X chromosome may play a role in the pathogenesis of early-onset female pattern hair loss.
24 citations
,
August 2016 in “JAMA Facial Plastic Surgery” This study found that men appearing in photos after a hair transplant were perceived by observers as younger, more attractive, more successful, and more approachable compared to their pretransplant images.
23 citations
,
January 2009 in “Veterinary Dermatology” This study found that recombinant hepatitis B vaccine may increase the risk of alopecia areata onset in older predisposed mice but larger trials suggest this effect might lie within normal variation.
22 citations
,
July 2024 in “Archives of Plastic Surgery” This review detailed the types and mechanisms of injectable "skin boosters" and evaluated their effectiveness and safety for mitigating age-related skin changes, providing insight into their use in contemporary dermatological practice.
21 citations
,
January 2018 in “The Korean Journal of Physiology and Pharmacology” This study found that human umbilical cord blood mesenchymal stem cells promoted hair growth by advancing anagen onset and increasing hair follicle regeneration in an in vivo model.
21 citations
,
January 2003 in “Skin pharmacology and physiology” This study found that dutasteride completely suppressed the formation of 5alpha-dihydro metabolites in cultured human skin cells, suggesting its potential use in acne and androgenetic alopecia.