6 citations,
September 2019 in “Skin pharmacology and physiology” RCS-01 therapy is safe and may improve skin structure by affecting gene expression.
85 citations,
September 2013 in “International Journal of Molecular Sciences” Keratin 15 is not a reliable sole marker for identifying epidermal stem cells because it's found in various cell types.
16 citations,
February 2018 in “BMC Genomics” Certain genetic markers linked to reproductive potential were identified by their impact on a protein's ability to bind to genes.
12 citations,
January 2019 in “Sleep medicine” Night shift work disrupts the body's natural clock genes.
58 citations,
November 2020 in “International Journal of Molecular Sciences” SHBG may be a useful early indicator and treatment target for PCOS.
39 citations,
July 2013 in “Journal of dermatological science” Hair microRNAs could be effective biomarkers for diagnosing scleroderma.
2 citations,
March 2018 in “Biotechnology Letters” Scientists created a new cell line from Cashmere goat hair and found that cytokeratin 13 is a unique marker for certain skin cells.
1 citations,
May 2017 in “InTech eBooks” Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.
2 citations,
May 2023 in “International Journal of Molecular Sciences” Gene expression in hair follicles can help diagnose methamphetamine use disorder.
1 citations,
December 2016 Researchers created a model to understand heart aging, highlighting key genes and pathways, and suggesting miR-208a as a potential heart attack biomarker.
24 citations,
April 2017 in “Oncology Reports” The hair keratin gene KRT81 is found in both normal and breast cancer cells and helps them invade surrounding tissues.
85 citations,
May 2019 in “Journal of neuroendocrinology” The article concludes that better understanding gene regulation related to seasonal changes can offer insights into the mechanisms of seasonal timing in mammals.
18 citations,
October 2021 in “Frontiers in Physiology” Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.
January 2018 in “Stem cell biology and regenerative medicine” The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.
4 citations,
January 2017 in “Biological & pharmaceutical bulletin” Inhibiting ALOX12 can help hair cuticle maturation by increasing S100A3 citrullination.
September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” Not having enough cystatin M/E protein causes less hair growth and dry skin.
11 citations,
April 2015 in “EBioMedicine” JAK inhibitors may help treat Alopecia Areata but need careful monitoring due to side effects.
11 citations,
April 2013 in “Journal of Proteomics” Found different proteins in balding and non-balding cells, giving insight into hair loss causes.
3 citations,
May 2023 in “Precision clinical medicine” Researchers found four genes that could help diagnose severe alopecia areata early.
256 citations,
October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Growing human skin cells in a 3D environment can stimulate new hair growth.
222 citations,
September 2016 in “JCI insight” Tofacitinib is safe and effective for severe alopecia areata, but hair loss may return 2 months after stopping treatment.
196 citations,
September 2016 in “JCI insight” Ruxolitinib effectively regrows hair in most patients with severe hair loss.
31 citations,
July 2017 in “Clinical Science” MicroRNAs are important for skin health and could be targets for new skin disorder treatments.
28 citations,
May 2017 in “Molecular ecology” Researchers found genes that control hair color and growth change before the visible coat color changes in snowshoe hares.
23 citations,
January 2021 in “Scientific Reports” Adding human blood vessel cells to hair follicle germs may improve hair growth and quality.
22 citations,
January 2017 in “Advanced Healthcare Materials” The hydrogels help harvest cells while preserving their mechanical memory, which could improve wound healing.
13 citations,
December 2018 in “Development, Growth & Differentiation” Sex hormones, especially estradiol, can change chicken feather shapes and colors.
11 citations,
March 2021 in “Journal of Bioscience and Bioengineering” Adding human fat-derived stem cells to hair follicle grafts greatly increases hair growth.
November 2023 in “BMC genomics” The study concluded that the arachidonic acid pathway and the protein KRT79 play a role in determining the fineness of cashmere.
January 2019 in “Advances in stem cells and their niches” Skin health and repair depend on the signals between skin stem cells and their surrounding cells.