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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Early onset baldness in men may indicate a condition similar to PCOS, linked to heart disease, diabetes, and prostate issues.

Cimicifuga racemosa extract may help prevent and treat prostate issues by inhibiting 5α-reductase.

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

5α-reductase inhibitors increase the risk of sexual dysfunction, especially in men with enlarged prostate.

Finasteride effectively treats enlarged prostate and male baldness, improves symptoms of hirsutism in women, but doesn't work for acne, and may delay prostate cancer progression with few side effects.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

Finasteride effectively treats BPH, but needs more trials to understand potential.

Finasteride improves urinary function in men for 2 years.

Endurance exercise may help BPH by lowering hormones and inflammation.

Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.

Tadalafil is effective for treating urinary symptoms in men with BPH.

MENT could be a better option than testosterone for male hormone therapy and birth control because it works well at lower doses and has fewer side effects on the prostate.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

Using finasteride with TIP extends time off period for prostate cancer patients.

ERβ has potential in treating prostate cancer and neurodegenerative diseases, but human studies are needed before clinical use.

New compounds may help treat prostate cancer by reducing cell growth.

Finasteride works better than Permixon in reducing dihydrotestosterone levels.

Lovastatin doesn't improve lower urinary tract symptoms treatment.

5-alpha reductase inhibitors can cause sexual, neurologic, endocrine, and cardiovascular side effects, but these are rare and usually stop after ending treatment.

Herbal treatments can help with early-stage BPH symptoms, but more research is needed.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

α-Blockers and 5-ARIs for BPH can cause sexual dysfunction, including erectile and ejaculatory issues.

Finasteride can cause sexual dysfunction, sperm changes, and affect bone density and metabolism.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

The document concludes that sex hormones and related compounds have various effects on health, with both potential benefits and risks.