This critical review highlights the anti-carcinogenic properties of luteolin, a plant flavonoid, and examines how encapsulating luteolin in nanoformulations may overcome its bioavailability challenges, potentially enhancing its effectiveness as a safer cancer treatment according to this source.
August 2024 in “Drug Design Development and Therapy” This review explores the biological applications and pharmacokinetics of decursin, a compound isolated from Angelica gigas, highlighting its potential neuroprotective, anti-inflammatory, and anticancer properties based on in vitro and in vivo studies.
June 2024 in “International Journal of Nanomedicine” This review outlines recent progress in CRISPR/Cas9 genome editing, discussing its structure, mechanisms, and the use of genetic, chemical, and physical strategies to enhance precision and reduce off-target effects despite some persistent challenges for clinical application.
May 2024 in “Scientific African” This research used computational methods to identify potential new treatments for benign prostatic hyperplasia, finding three compounds from Ghanaian plants with promising binding energy against 5alpha reductase 2 compared to existing drugs, yet further in vitro validation is necessary to confirm their efficacy.
April 2024 in “Current research in nutrition and food science” This study found that a food supplement improved skin moisturization, elasticity, and thickness, reduced telogen hair density, and enhanced nail status in women with mild-to-moderate aging signs after 84 days.
April 2024 in “Journal of translational medicine” In this study, the researchers identified MJ04, a selective JAK3 inhibitor, as a promising candidate for promoting hair growth, demonstrating efficacy in both animal models and human hair follicle assays with a favorable safety and pharmacokinetic profile.
January 2024 in “Diagnostics” This literature review found that Long COVID is a complex condition involving multiple body systems, influenced by factors like pre-existing conditions and vaccination status, with differing manifestations and persistence, complicating diagnosis and treatment efforts.
January 2024 in “Metabolites” This review highlights the importance of standardizing pre-analytical procedures for collecting and extracting samples from uncommon biological specimens like breast milk and sweat in clinical metabolomics, to enhance diagnostic and biomarker discovery efforts while minimizing contamination and bias.
January 2024 in “Current research in toxicology” This review reports that thallium poisoning causes severe neurological damage, with early gastrointestinal symptoms and later neurological dysfunction, and highlights the importance of early diagnosis and Prussian blue as an effective antidote.
January 2024 in “Biochemistry Research International” This study found that compounds from Ziziphus spina-christi roots exhibited promising antibacterial and antioxidant activities, supporting its traditional medicinal use.
November 2023 in “Plants” This study evaluated compounds from Jatropha cordata bark, finding that a sterol mixture and n-heptyl ferulate demonstrated notable anti-inflammatory activity in murine macrophage cells without toxicity, suggesting potential for treating chronic inflammation.
September 2023 in “International journal of molecular sciences” In this study involving ICR mice, researchers found that Korean red pine bark extract improved cognitive functions impaired by TMT through mechanisms like antioxidant system protection, cholinergic and synaptic support, mitochondrial regulation, and reduction of neuro-inflammation and apoptosis.
February 2023 in “Journal of Ginseng Research/Journal of ginseng research” This review discusses the formation of gintonin LPAs in ginseng during processing and reports no new clinical results; the authors suggest potential benefits against degenerative diseases through LPA receptors.
November 2022 in “Arab Gulf Journal of Scientific Research” This review discusses the potential clinical benefits and functional properties of taurine as a conditionally essential amino acid, noting its presence in energy drinks, but reports no new experimental results.
September 2022 in “Frontiers in Bioengineering and Biotechnology” This study reports that taxifolin from enzymatic hydrolysis effectively regulates dermal papilla cell apoptosis and promotes hair growth by increasing IGF-1 and reducing TGF-β1, though it shows less inhibition of DHT compared to minoxidil.
November 2019 in “BMC veterinary research” This study concluded that moderate to severe alopecia in Belgian Blue crossbred calves was due to malabsorption of dietary fat caused by a mixing error of milk replacer.
This study identified seven new compounds from the plant Sansevieria trifasciata Prain and predicted that four of them may have better anti-alopecia activity than minoxidil through an in silico approach.
November 2025 in “SKIN The Journal of Cutaneous Medicine” In this phase 3 trial, baricitinib showed effectiveness and safety in both adolescents and adults with severe alopecia areata, with adolescents achieving higher response rates despite more severe baseline conditions, suggesting the advantages of early treatment.
September 2023 in “Research Square (Research Square)” This study describes the development of a prototype clinical expert system that uses a belief rule-based inference methodology to improve the risk stratification and diagnosis of polycystic ovary syndrome by addressing uncertainties in clinical data and domain knowledge.
15 citations
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October 2014 in “Journal of Investigative Dermatology” This review discusses the development of targeted therapies for basal cell carcinoma that interfere with Hedgehog signaling and reports no new research findings.
24 citations
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December 2019 in “PLoS ONE” This study validated the Black Identity, Hair Product Use, and Breast Cancer Scale (BHBS) as a tool to measure social and cultural factors related to hair product use and perceived breast cancer risk in Black women.
16 citations
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March 2011 in “Ophthalmic genetics” This case report documents a 63-year-old with Birt-Hogg-Dubé Syndrome who developed choroidal melanoma alongside multiple lid folliculomas, marking the first known association of these conditions.
January 2013 in “Kidney international” This report describes a clinical case of a 38-year-old man diagnosed with Birt-Hogg-Dubé syndrome, confirmed by genetic testing, highlighting the presentation of multiple renal tumors and bilateral lung cysts.
This study found that in beagles with benign prostate hyperplasia, finasteride treatment increased blood volume and decreased vessel leakiness in the prostate's parenchymal zone as shown by dynamic contrast-enhanced MRI.
March 2024 in “Journal of Experimental & Biomedical Sciences/Biomedical Science Letters” In this study, BCC therapy reduced oxidative stress and cell damage in cardiomyocyte cells, suggesting it may serve as a new treatment alternative for heart disease.
60 citations
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October 2020 in “Nature Communications” This study found that small molecule AP-1 inhibitors may selectively target SMO inhibitor-resistant basal cell carcinoma cells characterized by specific markers, potentially enhancing combinatorial cancer therapies.
39 citations
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October 2012 in “Familial cancer” This review covers the molecular basis of Birt–Hogg–Dubé syndrome and its implications for potential therapeutic targets, but it does not report new experimental results.
2 citations
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January 1989 This article discusses the history and understanding of Tay syndrome, recognizing it as a distinct condition related to ichthyotic erythroderma, mental retardation, and brittle hair but reports no new clinical results.
This study identified a genetic locus associated with rhabdomyosarcoma susceptibility in mice and found that specific differentiation markers are linked to the regression of basal cell carcinoma.
November 2013 in “Hair transplant forum international” This article discusses categorization changes for Hair Transplant Surgeon members at the British Association of Hair Restoration Surgery and reports no clinical outcomes.