Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that ILK deficiency disrupts hair follicle development by impairing cell polarity and laminin-511 assembly, but these defects can be partially reversed with exogenous laminin-511.

In this study, Dsc 1 was highly expressed in certain layers of fetal epidermis and hair follicle but not in basal cells or oral mucosa, indicating its potential role in maintaining epithelial integrity.

The researchers reported that basal cell carcinoma tumor cells strongly express keratins typical of basal keratinocytes and some hair follicle components but lack differentiation markers, suggesting a follicular or pluripotent stem cell origin.

This study found that TAp63 and ΔNp63 isoforms in the p63 family interact with different transcription factors to regulate distinct transcriptional programs, affecting various biological functions like metabolic pathways, oxidative stress response, and epithelial morphogenesis in mouse epidermal cells.

Ovol2 is essential for normal skin and hair regeneration.

This study found that full thickness wounds in Lanyu pigs led to altered molecular expression and abnormal skin structure, without regenerating key epithelial cells thought to aid in skin regeneration.

This study found that Krox20 marks a diverse stem cell population in mouse hair follicles, which significantly contributes to the interfollicular epidermis and regulates epidermal homeostasis.

EGF receptors are crucial for skin cell growth and decrease with age.

This study proposes a model suggesting that the ratio of keratin 15 to keratin 14 in epidermal keratinocytes promotes a progenitor state and opposes differentiation, based on insights from both cell culture and transgenic mouse models.

This study categorizes the human fetal vaginal epithelium into four areas with distinct transcriptomic profiles, aiding potential advancements in vaginal reconstruction and drug delivery.

This study found that Wnt ligands secreted by the hair follicle epithelium are crucial for hair follicle regeneration in adults and could inform treatments for hair disorders like alopecia.

This study found that the Meibomian gland shares structural and cytokeratin composition similarities with hair follicles, and plays a role in hyper-keratinisation observed in obstructive Meibomian gland dysfunction.

This study found HLA and beta 2-microglobulin antigens in various skin structures, with specific localization patterns in keratinocytes and hair follicle components, but not in eccrine or apocrine glands.

Stem cells in mouse nails are found in the nail matrix and may control nail growth.

This study found that a truncated region of the K5 promoter directs expression in stratified epithelia, particularly in epidermis, hair follicles, and tongue, potentially involving specific keratinocyte nuclear proteins in regulation.

This study found that as few as 90 base pairs of the K5 promoter directed keratinocyte-preferred expression in stratified epithelia, especially in epidermis, hair follicles, and tongue, showing cell type specificity.

This review discusses cornea-specific keratin expression patterns in human and mouse development and reports no new experimental results; it highlights the need for investigating keratin mutations' role in pathology.

MCSP may help identify and regulate skin stem cells, affecting hair growth and regeneration.

This study revealed that basement membrane dynamics are crucial to hair follicle development, influencing progenitor cell behavior and cell division patterns in developing mouse hair follicles.

In this study, the researchers reported the detailed anatomical structure of horse skin, including the composition and organization of the epidermis, dermis, and associated glands and follicles.

In this study, researchers mapped gene expression in developing hair follicles to reveal unknown cell populations and markers, suggesting early establishment of cell fates in hair placodes.

This study found that integrin alpha-6 and p63 may play a role in hair loss, with variable expression patterns in different types of alopecia observed in scalp biopsy samples.

This study suggests that basonuclin in keratinocytes is likely a regulatory molecule linked to maintaining proliferative capacity and preventing terminal differentiation rather than a cell cycle marker.

This study highlights a case where progressive baldness initially diagnosed as alopecia universalis was attributed to a basal cell hamartoma of each hair follicle, stressing the importance of skin biopsies for unusual alopecia cases.

This article reports a case of late onset linear and unilateral basaloid follicular hamartoma in an elderly male, highlighting the clinical presentation, histopathological findings, and planned treatment approach.

This review discusses recent advances in understanding hair follicle stem cell dynamics and interactions, but it reports no new experimental findings.

In this study, researchers reported that a keratinocyte growth factor-Ig fusion protein could specifically detect and localize KGFRs in epithelial tissues, suggesting a method for histochemical detection of growth factor receptors.

The study concluded that all parts of the normal human Meibomian gland ductal system show signs of early keratinisation, supporting the idea that these glands are akin to "hair follicles without a hair shaft.

In this case report, a rare melanotrichoblastoma tumor was identified in a 51-year-old female following the histological and immunohistochemical analysis of a lesion on the pubo-inguinal area, presenting with strong epithelial marker positivity and a low proliferative index.

This article reviews various aspects of skin cancer, including animal models, molecular mechanisms, immunity roles, and potential chemoprevention strategies, but reports no new experimental results.