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Apremilast may help treat hair loss in alopecia areata.

This review discusses how modern lifestyle factors affecting gut health may contribute to Alopecia Areata in genetically predisposed individuals, reporting no new results but suggesting the need for long-term interventions.

Alopecia areata patients have more activated T cells in their blood, which may help in developing treatments.

This review discusses the clinical characteristics, diagnosis, and treatment of alopecia areata, exploring potential environmental, immunological, and genetic factors involved in its development, but reports no new research findings.

This study discusses the immune dysregulation observed in individuals with Down syndrome, highlighting their increased risk for autoimmune skin conditions, but does not yet clarify the molecular mechanisms behind this profile.

In this study, iNKT10 cells were found to play a significant role in preventing and treating alopecia areata in a humanized mouse model, suggesting these cells could have potential in managing related autoimmune disorders.

Regulatory T cells help prevent autoimmunity and have potential for treating autoimmune diseases.

Upadacitinib improved Crohn's disease, atopic dermatitis, and alopecia areata in one patient.

This review discusses the mechanisms underlying immune tolerance failure in alopecia areata and highlights potential therapeutic avenues for restoring hair growth and achieving sustained remission, but reports no new clinical results.

This research discusses the complex immune pathogenesis of alopecia areata and highlights the success of Jak inhibitors and IL-4Rα antagonists, while IL-17A and PDE4 inhibitors showed limited efficacy; controlled trials are advocated to better understand cytokine involvement.

This review examines the role of IL-15 in alopecia areata treatment but reports no clinical results, as there are currently insufficient studies to determine its therapeutic potential.

In this study, a 12-year-old intact male wirehaired fox terrier with testicular neoplasia and alopecia universalis was successfully treated for the alopecia using a combination of ciclosporin and ketoconazole, leading to complete hair regrowth.

This review discusses the National Alopecia Areata Foundation's efforts to evaluate and advance alopecia areata research, focusing on immunology and drug development, and reports no new clinical results.

This study identified CD28, GZMB, and CD1C as key immune regulators in alopecia areata, highlighting CD28 as a potential therapeutic target with a promising safety profile, using a proteome-anchored multi-omics approach to uncover actionable targets for this autoimmune hair-loss disorder.

In this review, researchers reported that pyroptosis, a type of inflammatory cell death linked to inflammasome activity, is a key factor in the pathogenesis of alopecia areata and may present new therapeutic opportunities, though most treatments are still in early research stages.

In this study, researchers demonstrated that CD4 T cells from skin-draining lymph nodes in mice with alopecia areata can transfer the disease to recipient mice, revealing a critical role for CD4 T cells in disease development and suggesting potential therapeutic targets.

This source describes a case where a patient with Crohn's disease experienced remission of alopecia universalis after a colectomy, suggesting that addressing the intestinal inflammatory source might influence autoimmune manifestations like hair loss.

This study investigated alopecia areata in a mouse model, finding that tofacitinib may inhibit disease progression by modulating linoleic acid metabolism and magnesium pathways, particularly affecting CD8+ T cell infiltration in hair follicles, offering insights for potential treatments.

This case study reported that homeopathic treatment focusing on emotional stress and immune support led to positive outcomes in a patient with alopecia totalis following emotional trauma, suggesting a potential benefit of addressing both physical and emotional factors.

This study described a rare case of bullous pemphigoid presenting as cicatricial alopecia in a Hispanic female, successfully treated with a combination of oral methotrexate and topical steroids.

This study developed a mathematical model to explore the interactions between hair cycle dynamics and immune system activity in alopecia areata, providing insights into disease progression and potential targets for treatment by simulating immune response effects on hair follicles.

This review concluded that interleukin-17 is involved in the development of female-pattern baldness, suggesting a potential inflammatory role in the condition’s underlying causes.

This study found that patients with alopecia areata had significantly lower frequencies of IL-10 producing CD19+CD24hiCD38hi regulatory B cells compared to healthy volunteers, suggesting a potential role for these cells in the autoimmune response seen in the condition.

This case report details a 37-year-old woman with alopecia areata who experienced significant hair regrowth after psychological stress-triggered hair loss, following treatment with topical corticosteroids and tofacitinib.

This chapter reviews fungal skin diseases in pigs, including urticarial and autoimmune conditions, but does not report new clinical findings.

This review examines the immunological aspects of alopecia areata, focusing on genetic, neuroimmunological, and immune privilege factors, but does not report new clinical findings.

In this study, a 55-year-old man with a localized patch of alopecia areata achieved hair regrowth through intralesional triamcinolone acetonide injections, demonstrating this treatment as an effective initial therapy for localized alopecia areata.

In this review, researchers explored the multifaceted role of NF-κB signaling in various biological processes and diseases, including its interactions with other pathways, and discussed possible therapeutic approaches targeting this pathway for treating conditions like cancer, autoimmune disorders, and COVID-19.

This study found that targeting IL-17 signaling in aged skin reduces inflammation and delays age-related traits, suggesting a potential strategy to prevent age-associated skin ailments.

This study examines the similarities and differences in the pathogenesis of autoimmune conditions alopecia areata and vitiligo, highlighting shared features like immune cell involvement and cytokine pathways, while noting differing immune responses in skin and hair.