Upadacitinib in Concurrent Crohn's Disease, Atopic Dermatitis, and Alopecia Areata: A Case Report

July 2023 in “ Journal of the European Academy of Dermatology and Venereology ”

D. Novielli, Caterina Foti, Mariabeatrice Principi, Edoardo Mortato, Paolo Romita, P. Dell'Aquila, A. Di Leo, Francesca Ambrogio

Upadacitinib Janus kinase inhibitor alopecia areata autoimmune conditions skin hair

Studysummary Upadacitinib improved Crohn's disease, atopic dermatitis, and alopecia areata in one patient.

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Alopecia Areata Incognita and Diffuse Alopecia Areata: Clinical, Trichoscopic, Histopathological, and Therapeutic Features of a 5-Year Study

research Alopecia Areata Incognita and Diffuse Alopecia Areata: Clinical, Trichoscopic, Histopathological, and Therapeutic Features of a 5-Year Study

23 citations , September 2019 in “Dermatology practical & conceptual”

This study analyzed the features of alopecia areata incognita and diffuse alopecia areata, finding distinct patterns in hair loss regions and trichoscopic signs, and noted a benign course responsive to topical steroid therapy.

research JAK Inhibitors for Alopecia Areata: A Systematic Review and Meta-Analysis

130 citations , February 2019 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

This study found that JAK inhibitors for alopecia areata showed promising response rates, with 72.4% of 289 cases responding, and oral administration achieving better outcomes than topical treatment, but recurrence occurred when treatment stopped. Further large-scale studies are needed to confirm these findings.

research Alopecia Areata: A Possible Extraintestinal Manifestation of Crohn's Disease

33 citations , June 2012 in “Journal of Crohn's and colitis”

This review discusses the role of immune responses, especially Th1 cytokines, in alopecia areata pathogenesis and reports no new research findings.