Scarring Alopecia in a 66-Year-Old Woman

    February 2025 in “ JEADV Clinical Practice ”
    Sergio Castillo Pinto, Lina M. Isaza-Valencia, Isabel Cristina Cuellar Rios
    TLDR A rare autoimmune disease caused the woman's scalp blisters and hair loss, successfully treated with medication.
    A 66-year-old woman presented with scarring alopecia and blistering on her scalp and periocular area, initially suspected to be herpes zoster or lichen planus pemphigoides. Histopathology and direct immunofluorescence confirmed a diagnosis of Brunsting-Perry Pemphigoid (BPP), a rare autoimmune blistering disease. BPP is characterized by subepidermal bullae and cicatricial alopecia, with antibodies targeting BP180 or BP230 antigens. Treatment with prednisolone and topical clobetasol, followed by methotrexate, led to complete healing. This case highlights the importance of considering BPP in cicatricial alopecia diagnoses and utilizing the salt-split test for diagnosis when serologic tests are unavailable. This is the third reported case of BPP in a Hispanic female.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 679 results

      community scarring alopecia awareness in this community

      in Chat  33 upvotes 3 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      by nkrata in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Quote from Pelage (PP-405) Spokesperson...

      in Research/Science  120 upvotes 4 months ago
      Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

      community Losing Hair on Dutasteride? You might have LPP

      in Research/Science  95 upvotes 1 year ago
      Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

    Related Research

    1 / 1 results