Alopecia Universalis in a Dog with Testicular Neoplasia
September 2016
in “
Veterinary dermatology
”
alopecia universalis testicular neoplasia bilateral interstitial cell tumors Sertoli cell tumors seminoma mural folliculitis peribulbar mucinosis lymphocytic bulbitis anagen hair follicles alopecia areata ciclosporin ketoconazole hair loss testicular cancer skin inflammation mucinosis hair follicle inflammation hair growth phase autoimmune hair loss cyclosporine Nizoral
TLDR A combination of ciclosporin and ketoconazole can effectively treat severe hair loss in dogs.
A 12-year-old intact male wirehaired fox terrier presented with symmetrical generalized alopecia and testicular enlargement, which was diagnosed as bilateral interstitial cell tumors, Sertoli cell tumors, and a unilateral seminoma. Post-castration, the alopecia worsened, and skin biopsies revealed moderate, multifocal mural folliculitis, peribulbar mucinosis, lymphocytic bulbitis, and targeting of anagen hair follicles. Immunophenotyping showed a population of well-differentiated, small CD3-positive T lymphocytes, indicating alopecia areata rather than lymphoma. Treatment with ciclosporin (4.6 mg/kg) and ketoconazole (4.6 mg/kg) led to complete hair regrowth. The study concluded that ciclosporin, combined with ketoconazole, can effectively treat alopecia universalis in dogs, and skin biopsies are essential for accurate diagnosis.
