1 citations
,
September 2016 in “Acta Chromatographica” This study validated a new RP-HPLC method for accurately determining doxazosin mesylate and finasteride in bulk powders and capsule formulations.
54 citations
,
January 2021 in “Biophysics Reports” This review highlights the current progress and application pros and cons of various cell-based screening platforms in drug discovery, discussing challenges and potential improvements for these innovative methods.
15 citations
,
March 2007 in “BioTechniques” This study introduced a new in vivo angiogenesis assay using Gelfoam implanted in ND-GFP transgenic mice to efficiently identify angiogenesis stimulators and inhibitors through GFP visualization.
4 citations
,
January 1993 in “Clinical Chemistry and Laboratory Medicine (CCLM)” This study developed a highly sensitive fluorescent assay for measuring enzyme activity in single hair follicles, allowing the efficient analysis of over 100 samples per day.
3 citations
,
February 2015 in “Scientific Research and Essays” This study found that S. rautanenii bark extract has an anti-proliferative effect on D. dorotocephala, suggesting it may have potential anticancer properties when evaluated using inexpensive planaria assays.
13 citations
,
February 2006 in “Analytical Biochemistry” This study reported a simple and validated gas chromatography method to accurately measure finasteride in tablets, showing equivalency to the official method with no significant differences.
6 citations
,
November 2022 in “Forensic Science Medicine and Pathology” This study demonstrated that genetic markers can predict human ear morphology with moderate to good accuracy, potentially aiding forensic identification in crime scene investigations where traditional DNA matches are unavailable.
3 citations
,
January 2012 This study developed and validated an RP-HPLC-PDA method for accurately estimating Tamsulosin and Finasteride in bulk and tablet forms, achieving precise detection and linearity within specified concentration ranges.
April 2018 in “Journal of Investigative Dermatology” This study found that patients taking hydroxychloroquine had a significantly higher likelihood of indeterminate QuantiFERON-TB Gold test results compared to those not on the medication, independent of other immunosuppressive drug use.
131 citations
,
July 2009 in “Experimental Dermatology” This review discusses the development and advances in studying trichogenic dermal cells for hair follicle morphogenesis, summarizing methods, bioassays, and molecular markers, but reports no new research findings.
111 citations
,
February 2017 in “Antiviral research” In this study, researchers discovered that several compounds, including brequinar and 6-azauridine, exhibit significant anti-Zika virus activity using a high-throughput screen assay.
4 citations
,
January 2013 in “Humana Press eBooks” This chapter describes procedures for isolating and purifying murine epithelial progenitors and assessing their ex vivo propagation capacity, but presents no new experimental results.
10 citations
,
June 2016 in “Cell Transplantation” This study suggests that using sebaceous glands from rat tail skin samples may effectively capture hair follicle stem cells, potentially aiding skin regenerative medicine when available tissue is limited.
2 citations
,
February 2024 in “STAR Protocols” In this research, an optimized protocol was developed for dissociating human scalp tissue to produce high-quality single-cell suspensions suitable for single-cell RNA sequencing, aimed at studying the transcriptomics of human hair follicles.
199 citations
,
July 2007 in “General and Comparative Endocrinology” In this study, researchers found a significant positive association between cortisol levels in hair and feces of domestic cats and dogs, suggesting hair cortisol assays could be a viable option for monitoring chronic stress.
11 citations
,
August 2009 in “Expert Opinion on Drug Discovery” This review discusses current challenges in selective androgen receptor modulator discovery and preclinical evaluation and reports no new results, emphasizing the need for basic research to improve safety and selectivity.
5 citations
,
October 2022 in “Materials Research Express” This study found that zinc oxide and fucoidan-loaded chitosan nanofiber scaffolds may enhance wound healing and provide antibacterial protection against common surgical pathogens in vitro.
November 2015 in “Journal of the Korea Academia-Industrial cooperation Society” This study established a stable cell line for CRF1 receptor screening, which can be used to develop functional cosmetics and modulators potentially affecting hair re-growth.
77 citations
,
April 2016 in “Science Advances” Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.
20 citations
,
September 2015 in “Protein expression and purification” This study demonstrated that safflower seeds can be engineered to express oleosin-FGF10, which showed a dose-dependent effect on cellular proliferation, potentially facilitating scalable protein production.
19 citations
,
January 2013 in “Frontiers in Neuroanatomy” This study demonstrates a method using intravital imaging to observe sensory hair-cell development and regeneration in zebrafish, which may facilitate assays for drug discovery related to aural function preservation.
11 citations
,
July 2021 in “Physiologia Plantarum” In this study, the gene SlPHL1 was identified as a transcription factor in tomatoes that enhances phosphate starvation responses by upregulating specific genes.
9 citations
,
October 2010 in “Journal of the American Academy of Dermatology” Iron deficiency might cause hair loss, but better testing is needed.
8 citations
,
July 2022 in “International Journal of Molecular Sciences” This study found that in estrogen receptor-positive breast cancer cells, 17β-estradiol repressed polyamine oxidase transcription by interacting with AP-1 sites on its promoter.
3 citations
,
June 2021 in “Frontiers in genetics” This study found that STAT3 directly inhibited the activity of the sheep FST gene promoter, consequently reducing cell proliferation and promoting a better understanding of hair follicle development mechanisms.
3 citations
,
June 2019 in “Asian Journal of Medical Sciences” This study found that explant transfers of human umbilical cord Wharton's jelly-derived mesenchymal stem cells can yield cells for five consecutive times, optimizing primary cell production and reducing costs.
This study developed a personalized microneedle that delivers finasteride directly to the skin, facilitating a sustained release and potentially reducing side effects associated with oral administration.
September 2024 in “International Journal For Multidisciplinary Research” This study highlights the significant pharmacological potential of Tridax procumbens, a plant with various therapeutic properties such as liver protection, immune modulation, and wound healing, though it notes that more research is needed to identify its active compounds and mechanisms for drug discovery.
This study found that germinated hemp seeds extract and exosomes from their calli can prevent androgenetic alopecia by modulating genetic, cellular, and immune responses in hair follicle dermal papilla stem cells and CD8+ T cells, with exosomes being more effective.
This study found that the ethanolic extract of Guazuma ulmifolia, or mutamba, showed only intermediate levels of phenolic compounds and low antioxidant activity in laboratory tests, suggesting limited potential in alleviating oxidative stress conditions like cancer or cardiovascular diseases.