13 citations
,
January 2020 in “Neuroscience” This study found that finasteride impaired object recognition memory and altered hippocampal dendritic structures in male 3xTg-AD mice, suggesting potential sex differences in Alzheimer's disease pathology.
13 citations
,
November 2012 in “PubMed” This study found that in men with sexual dysfunction, use of 5ARI may reduce sexual drive and spontaneous erections without worsening pre-existing erectile or ejaculatory issues.
12 citations
,
September 2017 in “Molecular and Cellular Endocrinology” This review analyzes how androgens impact sexual desire and reproductive behaviors, emphasizing molecular interactions, but provides no new clinical results.
12 citations
,
January 2016 in “Journal of Assisted Reproduction and Genetics” This study suggests that genetic variations in the AMH signal pathway may be linked to susceptibility and phenotype variations in PCOS among women with insulin resistance.
12 citations
,
October 2004 in “Experimental Gerontology” This review summarizes how common polymorphisms in androgen and estrogen receptor genes may influence aging-related symptoms and diseases in men, but it reports no new clinical results.
11 citations
,
August 2020 in “Diabetes” This study found that testosterone enhances insulin secretion in human pancreatic islets by being converted into DHT and E2, processes that are necessary for this effect.
11 citations
,
March 2016 in “Translational Andrology and Urology” This review highlights the potential therapeutic applications of nandrolone, an anabolic steroid, for male health, but notes that more human studies are needed due to limited existing literature.
11 citations
,
September 2012 in “Journal of obstetrics and gynaecology Canada” This review examines the scientific evidence on the short-term safety of testosterone therapy for treating hypoactive sexual desire disorder in women, without presenting new clinical results.
11 citations
,
November 2009 in “Sports Medicine” This review explores whether oligomenorrhoea in exercising women is a mild subclinical phenotype of PCOS or part of a spectrum of energy deficiency-related menstrual disturbances, without new clinical results.
11 citations
,
January 2007 in “Veterinary dermatology” This study found that administerating 10 mg/kg intramuscular fulvestrant did not stimulate hair regrowth in Pomeranian dogs with alopecia X, though higher doses may warrant further investigation.
11 citations
,
May 2002 in “The Journal of Urology” This study reports that long-term use of finasteride does not affect bone mineral density in men with benign prostatic hyperplasia over a four-year period.
11 citations
,
July 2001 in “APMIS. Acta pathologica, microbiologica et immunologica Scandinavica./APMIS” This review discusses the role of oestrogens in stimulating linear bone growth and pubertal changes in both boys and girls, highlighting their influence on the growth hormone-insulin-like growth factor axis; it reports no new clinical results.
10 citations
,
May 2019 in “International Journal of Environmental Research and Public Health” This study found that finasteride treatment in male rats altered steroid hormone homeostasis and caused kidney damage, suggesting potential risks for patients with renal dysfunction on androgen or antiandrogen therapy.
10 citations
,
May 2018 in “Neuropharmacology” This study suggests that inhibitors of steroidogenic enzymes may have therapeutic potential for certain behavioral disorders linked to dopaminergic hyperfunction, despite concerns about their endocrine impacts.
10 citations
,
October 2010 in “International Journal of Andrology” In this study, co-administration of finasteride with oral testosterone undecanoate in young men with induced hypogonadism had no significant effect on serum testosterone or dihydrotestosterone levels, likely due to TU's unique absorption route.
10 citations
,
January 2003 in “Seminars in reproductive medicine” This review covers the pathophysiology, diagnosis, evaluation, and treatment of hirsutism and reports no new clinical findings.
9 citations
,
May 2021 in “Molecules” This review discusses indole-based bifunctional aldose reductase inhibitors and antioxidants for diabetic complications and chronic inflammation-related pathologies, but reports no new clinical results.
9 citations
,
September 2020 in “Journal of Drugs in Dermatology” This study found that men have higher COVID-19 positivity, hospitalization, and death rates than women, even when accounting for age differences.
9 citations
,
March 2019 in “European Journal of Sport Science” This article discusses laboratory and physical markers that may help detect androgenic anabolic steroid abuse in athletes and reports no new primary research results.
9 citations
,
January 2007 in “Gynecological Endocrinology” This case report presents the first known instance of combined polycystic ovary syndrome and autoimmune polyglandular syndrome type 2 in a patient, exploring potential mechanisms for their interrelation.
8 citations
,
February 2009 in “Current Women's Health Reviews” This review discusses the impact of testosterone therapy on postmenopausal women's sexual function and well-being but notes a lack of long-term safety studies and debates on defining androgen insufficiency.
8 citations
,
January 1996 in “Gynecological Endocrinology” This review evaluates therapies for hyperandrogenism, highlighting cyproterone acetate as the preferred treatment due to its potency and tolerability in managing symptoms in women.
7 citations
,
June 2020 in “Translational Andrology and Urology” This study evaluated potential penile vascular changes and persistent adverse effects in men discontinuing 5α-reductase inhibitors for androgenic alopecia, but no new clinical results were reported.
7 citations
,
January 2019 in “The Aging Male” This article discusses post-finasteride syndrome as a distinct syndrome related to prolonged use of 5α-steroid reductase inhibitors, noting persistent side effects even after discontinuation and no new research results are reported.
7 citations
,
July 2014 in “Reproductive Biomedicine Online” This study found that, among fertile egg donors, the AR gene CAG polymorphism was associated with differences in antral follicle count but did not impact ovarian response to gonadotrophins.
7 citations
,
April 2012 in “Clinical investigation” This review examines existing research on transdermal testosterone for treating hypoactive sexual desire disorder, suggesting it improves female sexual function with minimal side effects but highlights the need for more long-term safety data.
7 citations
,
March 2011 in “Expert Opinion on Drug Safety” This review discusses the efficacy and safety of exemestane as a treatment for estrogen-receptor-positive breast cancer and reports no new clinical results.
7 citations
,
April 1995 in “Endocrinology” This study concluded that finasteride treatment did not adversely affect bone development or density in male rats, suggesting selective DHT deficiency is not harmful to the skeleton.
7 citations
,
January 1992 in “Adolescent and pediatric gynecology” This review discusses the unique challenges of diagnosing and managing polycystic ovarian syndrome in adolescents and reports no new clinical findings.
6 citations
,
April 2019 in “Endocrinology and Metabolism Clinics of North America” This study observed that testosterone therapy in transgender men enhances both physical and mental health, is safe in the short and middle term with proper follow-up, and highlights the need for endocrinologists to provide gender-affirming care despite its limited presence in medical education.