46 citations
,
November 1963 in “Journal of Histochemistry & Cytochemistry” In this study, researchers localized arginine and citrulline in rat hair follicles and found that arginine is abundant in trichohyalin droplets, while citrulline predominantly accumulates in the hardened inner sheath and medulla.
45 citations
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January 1977 in “Advances in experimental medicine and biology” Hair follicles have an enzyme that converts arginine to citrulline in proteins.
33 citations
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January 2007 in “Pediatric dermatology” This report describes a 3.5-year-old girl with argininosuccinicaciduria, highlighting congenital trichorrhexis nodosa as a notable feature associated with the disorder.
32 citations
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December 1965 in “The Lancet” Argininosuccinic aciduria can cause hair loss.
17 citations
,
October 2016 in “Artificial Cells Nanomedicine and Biotechnology” This study found that arginine-loaded lipidic nanoparticles improved hair follicle growth in male hamsters more effectively than an aqueous arginine solution.
15 citations
,
August 1991 in “American Journal of Medical Genetics” This study observed that a low-protein, arginine-supplemented diet improved the abnormal hair appearance in untreated patients with argininosuccinic aciduria.
14 citations
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June 2021 in “Journal of dermatological science” This study found that Argan press cake extracts stimulated hair growth and reduced inflammation and oxidative stress in human hair follicle dermal papilla cells, suggesting potential for anti-hair loss drug development.
14 citations
,
July 2001 in “American Journal of Human Genetics” Haplogroup X found in Altaian population supports Amerindian origin.
12 citations
,
February 2006 in “Lipids” This study found that in Japanese, German, and American females, changes in hair lipid patterns with age may reflect alterations in sebum excretion and affect hair texture.
10 citations
,
May 1974 in “American journal of diseases of children” This case report details a 4-year-old girl with arginosuccinic-aciduria, showing neurological symptoms and weakened hair, but the mechanisms behind these issues remain uncertain.
8 citations
,
November 1976 in “Journal of Investigative Dermatology”
7 citations
,
June 2021 in “Amino acids” This study found that protein arginine methylation levels in human hair may correlate with a cardiovascular biomarker in blood, suggesting hair sampling as a potential non-invasive method for cardiovascular risk assessment.
7 citations
,
January 2013 in “Journal of Cosmetics, Dermatological Sciences and Applications” This study found that incorporating Argania spinosa kernel oil and/or Theobroma grandiflorum seed butter into hair care formulations reduced protein loss in Caucasian hair dyed with an oxidative product.
5 citations
,
May 2022 in “Fashion and Textiles” This study found that Argan oil conditioner significantly enhanced tensile strength and retained hair color in bleached hair more effectively than Camellia oil.
5 citations
,
April 2013 in “Journal of Cosmetic and Laser Therapy” This study found that Argireline significantly reduced the depth of periorbital wrinkles in Chinese subjects and improved skin morphology in aged mice.
4 citations
,
January 2006 in “International Journal of Cosmetic Science” This study found that scanning electron microscopy with argon sputter etching visualizes hair lipids at the cell membrane complex as distinctive convex structures, shedding light on their role and localization in human hair.
2 citations
,
July 2022 in “PubMed” This study found that coconut oil clinically helps with brittle hair and hair infestation, while evidence for castor and argan oils improving hair growth or quality is weak.
1 citations
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October 2023 in “WORLD SCIENTIFIC eBooks” This study describes how the argan oil industry in southwestern Morocco, originally controlled by Amazigh women, has shifted to being largely dominated by the state and businessmen, with the majority of women now only involved in traditional nut cracking, despite mechanization of other production steps.
1 citations
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July 2022 in “Clinical and Experimental Dermatology” This study suggests that arginine and cysteine deficiency is not present in women with chronic telogen effluvium, indicating that amino acid supplementation may be unnecessary in nutrient-replete populations.
1 citations
,
February 2022 in “Biological Trace Element Research” In this animal study, applying a combination of inositol-stabilized arginine silicate complex and magnesium biotinate promoted hair growth but not nail growth.
1 citations
,
June 2019 in “Current developments in nutrition” This study observed that a combination of arginine silicate complex and magnesium biotinate significantly improved hair and nail growth in rats.
This study found that arginine deficiency in androgenetic alopecia patients is linked to increased oxidative stress and impaired hair follicle regeneration, with targeted arginine supplementation showing promise as a therapeutic strategy.
September 2018 in “Cosmetics” This study found that anisotropic osmolyte solutions may improve hair follicle turnover and condition in both in vitro and in silico models, as well as in human volunteers with hair disorders.
August 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This narrative literature review by Lustrao synthesizes existing research on six botanical ingredients used in Lustrao Hair Regrowth Oil, noting varying evidence levels with rosemary oil showing the clearest human clinical support for hair growth, particularly against minoxidil.
August 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This narrative literature review by Lustrao examines the existing research on six botanical ingredients in their Hair Regrowth Oil, finding varied evidence levels and highlighting rosemary oil's strong human clinical support for hair growth compared to minoxidil.
December 2025 in “Applied Sciences” This study examined argan oil inclusion complexes with β-CD, finding that these complexes improve the antibacterial efficacy, uniformity, and mechanical performance of hair treatment formulations while enhancing the durability of bleached hair, suggesting their potential as stable and effective cosmetic ingredients.
April 2024 in “Cosmetics” Different oils affect hair flexibility and strength, with their impact varying on whether hair is virgin or bleached.
This study found that androgenetic alopecia patients exhibited impaired arginine metabolism in balding hair follicles, suggesting that arginine supplementation may help preserve hair growth by counteracting mTOR signaling pathway disruption and offering potential as a treatment strategy.
June 2023 in “Italian journal of dermatology and venereology” In this study, researchers evaluated an oral supplement containing arginine, l-cystine, zinc, and vitamin B6, finding it effective as an adjuvant treatment for telogen effluvium, as indicated by improved hair quantity and diameter after three months in 18 patients.
September 2022 in “KnE medicine” This study found that hair tonic nanoemulsions containing 1%, 2%, and 3% argan oil promoted hair growth in mice over 21 days.