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Gene differences affect finasteride side effects in men with hair loss.

Using a certain drug on the skin can help prevent hair loss caused by pulling on the hair.

A specific pathway involving AR, miR-221, and IGF-1 plays a key role in causing common hair loss.

Phenylephrine may help prevent hair loss from pulling on the hair roots.

Finasteride treatment slows down hair loss, boosts hair growth, and may increase hair thickness or length, but it can cause side effects like decreased libido and depression in less than 1% of people.

Estrogen Receptor ß (ERß) is the main hormone controller in human skin and hair follicles, not Estrogen Receptor α (ERα) or the Androgen Receptor (AR).

Higher androgen levels and site-specific AR expression cause sex-related skeletal differences, and certain steroids can boost AR expression and androgen effects in bone cells.

Reduced AR gene methylation may cause early pubic hair growth in girls.

The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

Male yak hair growth is influenced by DHT synthesis, which is promoted by 5α-red1 and AR during growth phases, while E2 may inhibit growth through ERα.

AI and AR are improving cosmetic dermatology but face challenges like data quality and ethical concerns.

Higher levels of heat shock protein 27 and lower levels of miR-1 can increase AR levels, leading to hair loss in men.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

ERG increases SOX9, promoting prostate cancer growth and invasion.

Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Researchers developed new compounds that target the androgen receptor effectively with fewer side effects.

Male pattern baldness involves hormones and cell signals affecting hair growth.

Androgens have complex effects on hair growth, promoting it in some areas but causing hair loss in others, and our understanding of this is still evolving.

Insufficient androgen action in male fetuses can cause genital development issues due to genetic mutations or environmental chemicals.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

A three-month treatment with a GnRH agonist significantly lowered androgen levels and 5α-reductase activity in men with benign prostatic hyperplasia.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

Oral retinoids are effective for severe skin conditions but require careful use due to side effects.

Hormones and their receptors, especially androgens, play a key role in hair growth and disorders like baldness.