15 citations
,
August 2006 in “Journal of Cutaneous Pathology” This study found that diffuse alopecia in HIV-1-infected patients is characterized by higher rates of follicular stem cell apoptosis compared to controls, suggesting a hair cycle disturbance associated with the infection.
9 citations
,
November 2019 in “Scientific reports” This study isolated a bioactive peptide from Trapa japonica fruit and found that it may protect human dermal papilla cells from DHT-induced stress, suggesting potential for biomedical applications.
253 citations
,
March 1994 in “Developmental dynamics” This study suggests that programmed cell death plays a crucial role in shaping the structure of the human epidermis and its appendages during development.
78 citations
,
June 2013 in “Science” This study found that mice lacking the Sept4/ARTS gene had more hair follicle stem cells and improved wound healing, suggesting apoptosis regulation as a potential target in regenerative medicine.
50 citations
,
August 2021 in “Stem Cell Research & Therapy” This study reports that adipose-derived stem cells can protect against radiation-induced dermatitis in rats by reducing apoptosis through lowering Cathepsin F expression, suggesting a potential new therapeutic approach.
22 citations
,
September 1998 in “PubMed” This study found that the water fraction of Panax ginseng may reduce apoptosis and enhance medullary cell formation in the hair follicles of irradiated mice, suggesting a potential protective effect.
20 citations
,
February 2017 in “International Journal of Dermatology” This study found that the small molecule honokiol may protect against inflammation, collagen breakdown, and cell damage caused by cigarette smoke in skin cells cultured in vitro.
18 citations
,
February 2017 in “Molecular Medicine Reports” This study found that the Notch signaling pathway is suppressed in basal cell carcinomas and highly expressed in hair follicles, suggesting it might be a target for treatment strategies.
14 citations
,
January 2006 in “Skin pharmacology and physiology” This study found that procyanidin oligomers from apples and barley may stimulate hair growth by promoting hair epithelial cell proliferation and protecting them from apoptosis via MEK activation in a murine model.
5 citations
,
November 2021 in “Frontiers in Cell and Developmental Biology” Caffeine can damage hearing cells and affect hearing recovery after ear trauma.
3 citations
,
January 2018 in “Biomedical dermatology” This study found that epigallocatechin-3-gallate (EGCG) may reduce paclitaxel-induced apoptosis in human dermal papilla cells by regulating microRNA expression related to apoptosis and cell proliferation.
1 citations
,
October 2021 in “Jundishapur Journal of Natural Pharmaceutical Products” This study found that methanolic extract of Ficus carica leaves induced apoptosis and inhibited proliferation in B16F10 melanoma cells, suggesting potential anti-cancer properties for further investigation in melanoma.
November 2025 in “Frontiers in Cell and Developmental Biology” This study mapped a detailed genetic profile of goat hair follicle apoptosis, identifying key genes and regulatory factors involved in the hair cycle, offering new insights into programmed cell death.
December 2015 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found that estrogen treatment induced premature catagen and apoptosis in hair follicles of wild-type mice, while having no effect on mice lacking estrogen receptor α.
53 citations
,
September 2013 in “Journal of Investigative Dermatology” This study suggests that cultured hair follicle dermal sheath cup cells exhibit immune privilege properties, partly through the expression of PD-L1, which impacts co-cultured immune cells' behavior.
33 citations
,
October 2006 in “European Journal of Immunology” This study found that CD44 and CD49d together enhance signaling pathways in lymphocytes in mice with alopecia areata, influencing their activation and function.
26 citations
,
August 2019 in “Stem Cell Research & Therapy” This study found that PBX1 enhances the proliferation and reprogramming of hair follicle mesenchymal stem cells by activating the AKT/GSK3β signaling pathway, promoting NANOG expression, and inhibiting apoptosis.
21 citations
,
October 2017 in “Cell death and disease” This study found that the absence of the stress-responsive protein Sesn2 increased hair cell susceptibility to gentamicin in the inner ear, indicating Sesn2's potential protective role against aminoglycoside-induced damage.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that p21 is much more highly expressed in normal melanocytes compared to melanoma cells, suggesting a potential target for preventing melanoma progression through cell cycle repair processes.
January 2011 in “Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)” This study found that a combination of spermidin, rutine, and zeaxantine effectively reduced staurosporin-induced apoptosis in cultured hair follicle dermal papilla cells, potentially preventing the regression phase in the hair follicle cycle.
171 citations
,
July 2007 in “Journal of Investigative Dermatology” The researchers reported that DHT-inducible DKK-1 may play a significant role in DHT-driven balding by inhibiting hair follicle cell growth and promoting apoptosis in androgenetic alopecia.
58 citations
,
January 2006 in “Skin Pharmacology and Physiology” This study found that testosterone and 5α-dihydrotestosterone induced apoptosis in dermal papilla cells from nonbalding scalp regions, suggesting a high androgen stimulus can trigger cell death related to androgenetic alopecia.
13 citations
,
September 2021 in “Current Issues in Molecular Biology” This study suggests that D-panthenol may promote hair growth by enhancing cell viability, suppressing apoptosis markers, and elongating the anagen phase in human hair follicle cells.
November 2024 in “Journal of Investigative Dermatology” This study found that recombinant human ADM2 treatment inhibited cell proliferation and induced apoptosis in human hair follicles, contrasting with the previously documented pro-proliferative and anti-apoptotic functions of ADM2.
34 citations
,
September 2013 in “Urology” Long-term use of a certain medication can worsen erectile function in aged rats by damaging penile muscle cells.
20 citations
,
December 2013 in “PLoS ONE” This study found that β1 integrin-mediated signaling is crucial for the survival, adhesion, and migration of epithelial progenitor cells in human scalp hair follicles, with varying responses observed among cell subpopulations.
10 citations
,
August 2020 in “Acta histochemica” This study found that all-trans-retinoic acid (ATRA) inhibits mink hair follicle growth by reducing dermal papilla cell proliferation and inducing apoptosis, likely through the TGF-β2/Smad2/3 pathway.
9 citations
,
November 2021 in “Frontiers in Cell and Developmental Biology” This study found that PBX1 overexpression reduces hair follicle-derived mesenchymal stem cell senescence and apoptosis by alleviating ROS-mediated DNA damage, rather than enhancing DNA repair.
8 citations
,
November 2010 in “British journal of dermatology/British journal of dermatology, Supplement” This study found that calcitriol protects keratinocytes from the cell detachment and apoptosis caused by captopril exposure.
5 citations
,
July 2021 in “Basic & Clinical Pharmacology & Toxicology” This study found that nicotine caused damage to cochlear hair cells in vitro, and melatonin might protect against this damage, indicating its potential as a treatment for smoking-induced hearing loss.