The Premature Catagen Induced by Estrogen Was Accompanied with Advanced Apoptosis of Pre-Cortex Cells.

    December 2015 in “ OPAL (Open@LaTrobe) (La Trobe University) ”
    Huimin Hu, Shoubing Zhang, Xiaohua Lei, Zhili Deng, Weixiang Guo, Qiu Zhi-fang, Shuang Liu, Xinyue Wang, He Zhang, Enkui Duan
    TLDR Estrogen speeds up hair follicle cell death, causing early hair growth cycle changes, but only if a specific receptor is present.
    The study investigated the effects of estrogen on hair follicles (HFs) in wild-type (WT) mice, revealing that estrogen treatment induced premature catagen phase as early as the 4th day. This effect was not observed in estrogen receptor alpha (ER α) knockout mice, indicating the role of this receptor in the process. Additionally, after 3 to 4 days of estrogen treatment, precortex cells in the HFs exhibited signs of apoptosis, as evidenced by Tunel-positive staining and cleaved caspase-3 expression. These findings suggested that estrogen accelerated the catagen phase and apoptosis in hair follicles through its interaction with estrogen receptors.
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