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Stress can worsen skin and hair conditions by affecting the skin's immune response and hormone levels.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

Women with the NIH type of PCOS have more obesity and higher risk of diabetes and heart disease than those with other types of PCOS.

Hormone therapy for trans individuals is effective and generally safe in the short term.

Women with PCOS have heart-related issues not because of obesity, but due to insulin resistance and low adiponectin levels.

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

Blocking the virus's entry into cells by targeting certain pathways could lead to early COVID-19 treatments.

Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.

The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.

Human hair follicles produce and respond to erythropoietin, helping protect against stress.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

The conclusion is that the best initial treatment for hirsutism is usually oral contraceptives, with the addition of antiandrogens or insulin sensitizers if needed, and topical eflornithine or laser treatments as supplementary options.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Spironolactone improved blood vessel function and cholesterol levels in non-obese women with PCOS.

Bergamot may improve heart health, skin conditions, and mood, but more research is needed to confirm these benefits.

Prolactin may affect hair growth differently based on gender and scalp area.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Cell-based therapies using dermal papilla cells and adipocyte lineage cells show potential for hair regeneration.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

The study suggests that being overweight or obese, not PCOS itself, is strongly linked to insulin resistance.

Women with PCOS have unhealthy changes in their cholesterol particles that are not related to their body weight.

Women with PCOS who had antiandrogenic treatment before pregnancy had fewer complications than those without treatment.

Balding people may have higher heart disease risk.