TLDR Glucocorticoids can cause various health issues, but some treatments may help reduce these effects.
The document provides an extensive overview of various animal models used to study the effects of glucocorticoids, highlighting their impact on different physiological systems. Key findings include the protective role of PI3K inhibitors against glucocorticoid-induced skin atrophy, the adverse effects of glucocorticoids on skeletal muscle and bone, and their role in inducing conditions such as osteoporosis, insulin resistance, and hypertension. The review also discusses the mechanisms behind glucocorticoid-induced side effects, such as cataracts, myopathy, and alopecia, and explores potential therapeutic interventions to mitigate these effects.
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